Gene interactions and pathways from curated databases and text-mining

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BCL2 — PPP2CA

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lin et al., J Biol Chem 2006 : PP2A regulates BCL-2 phosphorylation and proteasome mediated degradation at the endoplasmic reticulum ... Knock down or pharmacological inhibition of PP2A caused degradation of phosphorylated BCL-2 and led to an overall reduction in BCL-2 levels
Deng et al., Blood 2009 (Hematologic Neoplasms) : By contrast, treatment of cells with C2-ceramide ( a potent PP2A activator ) or expression of the PP2A catalytic subunit (PP2A/C) inhibits Bcl2 phosphorylation, leading to increased p53/Bcl2 binding and apoptotic cell death ... Mechanistically, PP2A mediated dephosphorylation of Bcl2 in vitro promotes its direct interaction with p53 as well as a conformational change in Bcl2