Gene interactions and pathways from curated databases and text-mining

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BCL2 — IGF1

Text-mined interactions from Literome

Pugazhenthi et al., J Biol Chem 1999 : Thus, we have characterized a novel signaling pathway ( MAPK kinase 6/p38beta MAPK/MAPKAP-K3 ) that defines a transcriptional mechanism for the induction of the antiapoptotic protein Bcl-2 by IGF-I through the nuclear transcription factor cAMP-response element binding protein in PC12 cells
Fornoni et al., Am J Pathol 2001 : We investigated whether Bcl-xL and Fas/Fas-ligand were regulated by CsA in cultured podocytes and whether CsA induced apoptosis was prevented by HGF or IGF-I ... HGF, but not IGF-I , prevented apoptosis and restored Bcl-xL levels
Yamamura et al., Am J Physiol Heart Circ Physiol 2001 (Myocardial Reperfusion Injury) : IGF-I differentially regulates Bcl-xL and Bax and confers myocardial protection in the rat heart ... The present study examined the effect of IGF-I on the expression of Bcl-2 family proteins in the rat heart mitochondria in relation to myocardial protection against ischemia-reperfusion injury ... These results suggest that IGF-1 differentially regulates Bcl-xL and Bax in heart mitochondria, which may be causally related to myocardial protection against ischemia-reperfusion injury
Chrysis et al., J Neurosci 2001 (Nervous System Malformations) : IGF-I decreases caspase-3 availability and activity, increases the expression of anti-apoptotic Bcl-x ( L ) and Bcl-2 during early postnatal development, and decreases proapoptotic Bax and Bad expression at later developmental stages
Nakao et al., J Thorac Cardiovasc Surg 2001 (Disease Models, Animal...) : Immunohistochemical studies revealed that insulin-like growth factor 1 increased expression of the antiapoptotic Bcl-xL protein and inhibited expression of the proapoptotic Bax protein in motor neuron cells 24 and 48 hours after the operation
Gao et al., J Clin Endocrinol Metab 2001 (Leiomyoma...) : The present study was conducted to elucidate whether IGF-I affects apoptosis and Bcl-2 protein expression, an apoptosis inhibiting gene product, in cultured leiomyoma cells
Beierle et al., J Pediatr Surg 2002 (Neuroblastoma) : IGF-I protects neuroblastoma cells from apoptosis and increases Bcl-2 expression
Maruo et al., Steroids 2003 (Leiomyoma...) : Treatment with P4 augmented EGF and Bcl-2 protein expression, but inhibited IGF-I and TNFalpha expression in cultured leiomyoma cells
Kim et al., Mol Reprod Dev 2006 : In both IVF and SCNT embryos, anti-IGF-IR antibody along with IGF-I neutralized the effect of IGF-I on expression of Bcl-2 and Bax genes
Hung et al., Journal of neurosurgery. Spine 2007 (Disease Models, Animal...) : Furthermore, IGF-I attenuated caspase-9 cleavage, increased Bcl2 , and thus inhibited apoptosis after SCI
Hilmi et al., J Invest Dermatol 2008 (Melanoma) : Accordingly, IGF1 increases the mRNA levels and protein expression of antiapoptotic members of the BCL2 family -- BCL2 and BCL-X ( L ) -- and that of the inhibitor of apoptosis protein, survivin ... Accordingly, IGF1 increases the mRNA levels and protein expression of antiapoptotic members of the BCL2 family -- BCL2 and BCL-X ( L ) -- and that of the inhibitor of apoptosis protein, survivin
Singh et al., Growth Factors 2008 (Breast Neoplasms) : Furthermore, IGF-II differentially regulated the intracellular translocation of Bcl-2 and Bcl-X ( L ), a critical process in breast cancer progression to hormone-independence
Mani et al., Reproduction 2010 : IGF1 or FSH alone or both together had no effect on BCL2 expression
Chand et al., J Immunol 2012 (Chronic Disease...) : Intracellular insulin-like growth factor-1 induces Bcl-2 expression in airway epithelial cells ... Silencing the IGF-1 expression using short hairpin RNA showed that intracellular IGF-1 ( IC-IGF-1 ) was increasing Bcl-2 expression ... These studies demonstrate that IC-IGF-1 induces Bcl-2 expression in epithelial cells via IGF-1R and epidermal growth factor receptor pathways, and targeting IC-IGF-1 could be beneficial to treat chronic airway diseases
Chand et al., Am J Respir Cell Mol Biol 2012 (Acute Disease...) : Suppression of IGF-1 expression using retroviral shRNA blocked Bcl-2 expression in human and murine airway epithelial cells and Muc5ac in primary murine airway epithelial cells ... These findings show that acute inflammation induces IGF-1 to mediate Bcl-2 and Muc5ac expression in airway epithelial cells
Singleton et al., J Biol Chem 1996 : Finally, increased neuronal IGF-IR expression enhances the negative death regulator Bcl-xL
Wang et al., Endocrinology 1998 : To investigate IGF-I actions on apoptosis of H9C2 cardiac muscle cells, we have defined the effects of IGF-I on Bcl-2 , Bax, caspase 3, DNA fragmentation, and cell survival ... Interestingly, there is a compensatory rise in the abundance of Bcl-2 upon serum withdrawal and doxorubicin treatment, and IGF-I stimulation resulted in decreased induction of Bcl-2
Suzuki et al., FEBS Lett 1998 : It was also found that R-Ras and IGF-1 cooperatively induced Bcl-xL expression and inhibited caspase-3 activation