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BCL10 — CHUK

Pathways - manually collected, often from reviews:

• NCI Pathway Database BCR signaling pathway: IKK complex complex (CHUK-IKBKB-IKBKG) → CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7) (modification, collaborate)
  
• NCI Pathway Database BCR signaling pathway: CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7) → IKK alpha (CHUK) (modification, activates)
• Reactome Reaction: BCL10 → CHUK (indirect_complex) Shinohara et al., J Exp Med 2005, Sommer et al., Immunity 2005, Shinohara et al., Immunol Rev 2009
• Reactome Reaction: BCL10 → CHUK (reaction) Wang et al., Nature 2001, Zhou et al., Nature 2004, Shinohara et al., J Exp Med 2005, Häcker et al., Science's STKE : signal transduction knowledge environment 2006, Shinohara et al., Immunol Rev 2009, Zhang et al., Chin Med Sci J 2010
• WikiPathways T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection: Complex of MALT1-CARD11-BCL10 → Complex of IKBKG-IKBKB-CHUK (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BCL10 — CHUK (physical association, affinity chromatography technology) Poyet et al., J Biol Chem 2001*
• IRef Biogrid Interaction: BCL10 — CHUK (direct interaction, enzymatic study) Marinis et al., Mol Cell Biol 2012*
• MIPS CORUM CASP8-CHUK-IKBKB-MALT1-BCL10 complex: CASP8-CHUK-IKBKB-MALT1-BCL10 complex complex (BCL10-CASP8-CHUK-IKBKB-MALT1) Su et al., Science 2005
• MIPS CORUM BCL10-CHUK-BCL10-IKBKB complex: BCL10-CHUK-BCL10-IKBKB complex complex (BCL10-CASP8-CHUK-IKBKB) Su et al., Science 2005
• IRef Corum Interaction: Complex of IKBKB-CHUK-BCL10-CASP8-MALT1 (association, coimmunoprecipitation) Su et al., Science 2005
• IRef Corum Interaction: Complex of CASP8-BCL10-CHUK-IKBKB (association, coimmunoprecipitation) Su et al., Science 2005
• IRef Hprd Interaction: BCL10 — CHUK (in vivo) Poyet et al., J Biol Chem 2001*
• IRef Ophid Interaction: BCL10 — CHUK (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Patke et al., Curr Opin Immunol 2004 : BCR signaling leads to activation of the inhibitor of NF-kappa B kinase (IKK) complex via Carma1, Bcl10 and MALT1, whereas BAFF-R engagement promotes processing of NF-kappa B2 protein p100, which is dependent on NF-kappa B-inducing kinase (NIK) and IKK alpha
Sun et al., Mol Cell 2004 (Lymphoma, B-Cell, Marginal Zone) : Strikingly, only these oligomeric forms of BCL10 and MALT1 can activate IKK in vitro
Hinz et al., Science's STKE : signal transduction knowledge environment 2007 : IKK triggers Bcl10 degradation by the ubiquitin-proteasome system through phosphorylation of Bcl10 at other sites