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BAX — SIRT1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Ford et al., Cancer Res 2005
:
Combined gene knockout with RNAi cosilencing experiments indicate that
SIRT1 and Bcl-2 may suppress separable apoptotic pathways in the same cell lineage and that the SIRT1 regulated pathway is
independent of p53,
Bax , and caspase-2
Zhou et al., J Pharmacol Sci 2006
:
Silibinin increased the expression of anti-apoptotic Bcl-2 family protein Bcl-2, and up-regulation of
SIRT1 inhibited the translocation of
Bax from cytoplasm to mitochondria, which caused mitochondrial dysfunction and cell injury
Zhou et al., Yao Xue Xue Bao 2007
:
Silibinin increased the expression of anti-apoptotic Bcl-2 family protein Bcl-2, and up-regulation of
SIRT1 inhibited the translocation of
Bax from cytoplasm to mitochondria, which caused mitochondrial dysfunction and cell injury
Li et al., Pharmacology 2008
:
Furthermore, the release of proapoptotic cytochrome c from mitochondria was reduced by hyperoside, which increased the expression of antiapoptotic
SIRT1 and
inhibited the translocation of
Bax from cytoplasm to mitochondria