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BATF — STAT3
Text-mined interactions from Literome
Senga et al., Oncogene 2002
(Leukemia, Myeloid...) :
Stat3 dependent induction of
BATF in M1 mouse myeloid leukemia cells
Wang et al., Cell 2012
:
DNA damage induces
BATF in a
G-CSF/STAT3 dependent manner resulting in lymphoid differentiation of HSCs. BATF deletion improves HSC self-renewal and function in response to ?-irradiation or telomere shortening but results in accumulation of DNA damage in HSCs. Analysis of bone marrow from patients with myelodysplastic syndrome supports the conclusion that DNA damage dependent induction of BATF is conserved in human HSCs. Together, these results provide experimental evidence that a BATF dependent differentiation checkpoint limits self-renewal of HSCs in response to DNA damage