Gene interactions and pathways from curated databases and text-mining

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BAD — PRKAR2A

Pathways - manually collected, often from reviews:

  • BioCarta regulation of bad phosphorylation: BAD/BCL-2 complex (BAD-BCL2) → PKA complex (PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B) (modification, collaborate)
  • BioCarta regulation of bad phosphorylation: BAD/BCL-XL complex (BAD-BCL2L1) → PKA complex (PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B) (modification, collaborate)
  • KEGG Apoptosis: PRKACA/PRKACB/PRKACG/PRKAR1A/PRKAR1B/PRKAR2A/PRKAR2B/PRKX → BAD (protein-protein, inhibition)

Text-mined interactions from Literome

Affaitati et al., J Biol Chem 2003 : AKAP121 induction stimulates PKA dependent phosphorylation of the proapoptotic protein BAD at Ser ( 155 ), inhibits release of cytochrome c from mitochondria, and protects cells from apoptosis
Cieslak et al., Mol Cells 2007 : On the contrary, inhibition of PKA or specifically PKCdelta resulted in up-regulation of BAD