Gene interactions and pathways from curated databases and text-mining

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AKT1 — ATR

Text-mined interactions from Literome

Caporali et al., Mol Pharmacol 2008 (Breast Neoplasms...) : AKT is activated in an ataxia-telangiectasia and Rad3-related dependent manner in response to temozolomide and confers protection against drug induced cell growth inhibition ... Inhibition of ATM expression in colon cancer cells by siRNA did not impair TMZ induced activation of AKT, whereas siRNA mediated inhibition of ATR prevented AKT activation in response to the drug and increased cell chemosensitivity
Xu et al., Journal of oncology 2012 : Conversely, Akt is activated by DNA double-strand breaks ( DSBs ) in a DNA-PK- or ATM/ATR dependent manner and in some circumstances can contribute to radioresistance by stimulating DNA repair by nonhomologous end joining ( NHEJ )