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ATP5O — PRKAR2A

Text-mined interactions from Literome

Kiroytcheva et al., Kidney Int 1999 : In oxygenated MTALs, PKA mediated stimulation of Na+, K ( + ) -ATPase likely participates in the cAMP dependent stimulation of sodium reabsorption
Kurihara et al., Am J Physiol Cell Physiol 2000 : These results show that Na ( + ) -K ( + ) -ATPase of rat parotid gland acinar cells is regulated in vivo by membrane anchored PKA via AKAP rather than by free cytosolic PKA
Vinciguerra et al., Mol Biol Cell 2003 : The [ Na+ ] i-dependent increase in Na, K-ATPase cell-surface expression was prevented by PKA inhibitors H89 and PKI
Pedrosa et al., Cell Physiol Biochem 2004 : We have previously shown that the D1-mediated inhibition of Na+-K+-ATPase activity in OK cells involves the sequential activation of the AC-protein kinase A ( AC-PKA ) and the PLC-protein kinase C (PLC-PKC) pathways
Gomes et al., Eur J Pharmacol 2004 : Dopamine D ( 1 ) -mediated inhibition of Na ( + ), K ( + ) -ATPase activity in opossum kidney ( OK ) cells involves the sequential activation of the adenylyl cyclase-protein kinase A (PKA) and the phospholipase C-protein kinase C ( PKC ) pathways
Mordasini et al., American journal of physiology. Renal physiology 2005 : The effects of AVP on Na pump current and Na-K-ATPase cell surface expression were dependent on PKA activity but independent of increased apical Na ( + ) entry ... Therefore, stimulation of Na-K-ATPase cell surface expression by AVP is dependent on PKA but does not rely on alpha ( 1 ) -subunit phosphorylation on serine 943 in the collecting duct principal cells
Valverde et al., J Biol Chem 2005 : When CaM kinase II was blocked by its specific inhibitor KN-93, the Ca2+-ATPase activity decreased to the levels measured in the absence of calmodulin ; the unusually high Ca2+ affinity dropped 2-fold ; and the PKA mediated stimulation of Ca2+-ATPase was no longer seen
Pastor-Soler et al., Am J Physiol Cell Physiol 2008 : The PKA inhibitor myristoylated-PKI ( mPKI, 10 microM ) inhibited the apical accumulation of V-ATPase induced by 6-MB-cAMP ... We conclude that direct stimulation of PKA activity by cAMP is necessary and sufficient for the alkaline pH-induced accumulation of V-ATPase in clear cell apical microvilli
Hallows et al., Am J Physiol Cell Physiol 2009 : AMP activated protein kinase inhibits alkaline pH- and PKA induced apical vacuolar H+-ATPase accumulation in epididymal clear cells ... We have shown previously that protein kinase A (PKA) , acting downstream of soluble adenylyl cyclase stimulation by alkaline luminal pH or HCO ( 3 ) ( - ), induces V-ATPase apical membrane accumulation in clear cells ... Here we examined whether the metabolic sensor AMP activated protein kinase (AMPK) regulates this PKA induced V-ATPase apical membrane accumulation
Belleannée et al., Am J Physiol Cell Physiol 2010 : The PKA inhibitor myristoylated protein kinase inhibitor ( mPKI ) inhibited adenosine dependent V-ATPase apical accumulation, indicating the participation of the P1 A2B receptor
Gong et al., American journal of physiology. Renal physiology 2010 : Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP activated protein kinase ... In developmentally related epididymal clear cells, we showed previously that PKA , acting downstream of soluble adenylyl cyclase (sAC), induces V-ATPase apical membrane accumulation ... Here, we examined the regulation of V-ATPase subcellular localization in intercalated cells by PKA and AMPK in rat kidney tissue slices ex vivo
Lara et al., Arch Biochem Biophys 2010 : Cholera toxin, an activator of Gs protein, mimicked it ; ( 2 ) in the presence of Ang II, Ang- ( 1-7 ) increased the PKA activity 10-fold ; ( 3 ) the peptide inhibitor of PKA blocked the Ang- ( 1-7 ) effect on Ang II-stimulated Na+-ATPase ; ( 4 ) Ang- ( 1-7 ) reverses the Ang II-stimulated PKC activity ; ( 5 ) cAMP mimicked the Ang- ( 1-7 ) effect on the Ang II-stimulated Na+-ATPase
Alzamora et al., J Biol Chem 2010 : Finally, Ser-175 was necessary for PKA stimulated apical accumulation of the V-ATPase in a polarized rabbit cell line of collecting duct A-type intercalated cell characteristics ( Clone C )
Líbano-Soares et al., Arch Biochem Biophys 2011 : The inhibitory effect of PGE2 on PT Na+-ATPase activity involves G-protein and the activation of protein kinase A (PKA) because : ( 1 ) PGE2 increased [ 35S ] GTP?S binding ; ( 2 ) GDPßS abolished the inhibitory effect of PGE2 ; ( 3 ) PGE2 increased PKA activity ; ( 4 ) the inhibitory effect of PGE2 was abolished by PKA inhibitor peptide ... We observed that the PKA mediated inhibitory effect of PGE2 on PT Na+-ATPase activity requires previous activation of protein kinase C
Cheng et al., Am J Physiol 1997 : PKA mediated phosphorylation and inhibition of Na ( + ) -K ( + ) -ATPase in response to beta-adrenergic hormone