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ATP5O — NPY
Text-mined interactions from Literome
Ohtomo et al., Kidney Int 1994
:
Coexisting
NPY and NE synergistically
regulate renal tubular Na+, K ( + )
-ATPase activity
Ohtomo et al., Acta Physiol Scand 1996
:
The results indicate that
NPY regulates Na+, K ( + )
-ATPase through several signalling pathways : ( 1 ) In proximal tubule ( PT ) cells NPY increased intracellular calcium ... ( 2 )
NPY increased Na+, K ( + )
-ATPase activity in PT segments and this effect was also blocked by nifedipine ... CaMKII-Ala286 [ 281-302 ] a blocker of Ca2+/calmodulin dependent protein kinase II ( CaMKII ) inhibited the
NPY stimulated Na+, K ( + )
-ATPase activity ... ( 3 ) Calphostin C, an inhibitor of protein kinase C ( PKC ), did not inhibit
NPY stimulated Na+, K ( + )
-ATPase activity ... NPY attenuated forskolin stimulated cAMP production in renal tubules and exogenous cAMP counteracted the
NPY stimulated Na+, K ( + )
-ATPase activity
Holtbäck et al., Am J Physiol 1998
:
NPY abolished beta-agonist induced deactivation of Na+-K+-ATPase and
enhanced alpha-agonist induced activation of
Na+-K+-ATPase ... In our preparation, NE alone had no net effect but stimulated the
Na+-K+-ATPase activity in the presence of beta-adrenergic antagonists, as well as in the
presence of
NPY