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AKT1 — ATP5O

Text-mined interactions from Literome

Shaik et al., American journal of physiology. Renal physiology 2008 (Kidney Diseases) : Expressing constitutively active Akt in DCVC injured RPTC increased the levels of phosphorylated Akt in mitochondria, reduced the decreases in basal and uncoupled respirations, increased complex I-coupled state 3 respiration and ATP production, enhanced activities of complex I, complex III, and F ( 0 ) F ( 1 ) -ATPase , and improved DeltaPsi ( m )
Comellas et al., J Cell Sci 2010 : Insulin induced Akt activation is necessary and sufficient to promote Na ( + ) /K ( + ) -ATPase translocation to the plasma membrane ... Collectively, these results suggest that Akt plays a major role in Na ( + ) /K ( + ) -ATPase intracellular translocation and thus in alveolar fluid reabsorption
Lei et al., Am J Physiol Lung Cell Mol Physiol 2011 : In the present study, we assessed the role of Akt in Na-K-ATPase activity and the interaction between the PI3K and MAPK in response to T3 by using MP48 cells, inhibitors, and constitutively active mutants in the MP48 ( alveolar type II-like ) cell line ... Thus activation of Akt was required for T3-induced Na-K-ATPase activity in AECs and is sufficient in the absence of T3 ... In summary, in adult rat AECs T3-stimulated Src kinase activity can activate both PI3K/Akt and MAPK/ERK1/2, and activation of Akt is necessary for T3-induced Na-K-ATPase activity