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ARHGEF7 — IGF1
Text-mined interactions from Literome
Shah et al., Biochem J 2002
:
In the present study, we have shown that 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3,4-d ] pyrimidine ( PP1 ), a selective inhibitor of the Src family of non-receptor tyrosine kinases, interferes with the
activation of 70 and 85 kDa S6K gene products ( p70S6K1 and
p85S6K1 ) by insulin,
insulin-like growth factor 1 , sodium orthovanadate and activated alleles of phosphoinositide 3-kinase and H-Ras
Wrede et al., J Mol Endocrinol 2003
:
PMA inhibited IGF-I induced activation of PKB, correlating with inhibition of
IGF-I induced association of IRS-2 with the
p85 regulatory subunit of phosphatidylinositol-3 kinase
Luo et al., J Cell Biol 2005
:
To further understand the role of p85, we examined
IGF-1 dependent translocation of
p85alpha by using a green fluorescence protein ( GFP ) -tagged p85alpha ( EGFP-p85alpha )
Kwon et al., Endocrinology 2006
:
Similarly in cells expressing native SHP-2,
IGF-I induced SHP-2 binding to
p85 , whereas in cells expressing SHP-2/C459S, there was no increase
Xi et al., Endocrinology 2010
(Hyperglycemia) :
Mechanistic studies showed that knockdown of p66shc enhanced
IGF-I stimulated
SHPS-1/p85 , p85/SHP-2, and p85/Grb2 association, all of which are required for PI-3 kinase/AKT activation ...
IGF-I stimulated
p85 and AKT recruitment to the cell membrane fraction was altered in the same manner
Lim et al., BMC gastroenterology 2012
(Adenocarcinoma...) :
Luteolin reduced the
IGF-I induced tyrosine phosphorylation of IGF-IR and the association of
p85 with IGF-IR
Giorgino et al., J Biol Chem 1997
:
Stimulation with
IGF-I induced the association of
p85alpha and p85beta with IRS-1, and this was accompanied by increased amounts of the p110 catalytic subunit and markedly increased PI 3-kinase activity in IRS-1 immunoprecipitates