Gene interactions and pathways from curated databases and text-mining

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ARHGEF1 — MAPK3

Text-mined interactions from Literome

Garcia et al., J Biol Chem 2009 : These data suggest that n-6 dietary fatty acids stimulate a set of interactions that regulates cell adhesion through RhoA and ROCK II via a p38 MAPK dependent association of HSP27 and p115RhoGEF
Moey et al., J Pharmacol Exp Ther 2011 (Cardiomegaly) : We investigated the effects of North American ginseng ( Panax quinquefolius ), reported to reduce cardiac hypertrophy, on RhoA/ROCK and MAPK activation in ventricular cardiomyocytes exposed to leptin ( 50 ng/ml ) and the possible role of p115RhoGEF and p63RhoGEF in these responses ... These results demonstrate a potent inhibitory effect of ginseng against leptin induced cardiac hypertrophy, an effect associated with prevention of p115RhoGEF-RhoA/ROCK dependent p38 MAPK activation