Gene interactions and pathways from curated databases and text-mining

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ARG2 — IGF1

Text-mined interactions from Literome

Gasperi et al., J Clin Endocrinol Metab 2002 (Hyperparathyroidism) : GH secretion was evaluated by serum IGF-I levels, spontaneous mean GH secretion over two morning hours, and GH response to arginine ( ARG ) alone or combined with GHRH
Vendrame et al., Scand J Immunol 2007 : Effect of insulin-like growth factor-I on Leishmania amazonensis promastigote arginase activation and reciprocal inhibition of NOS2 pathway in macrophage in vitro ... Our data strongly suggest that IGF-I induces preferential expression and activation of Leishmania promastigote arginase , contributes to the alternative activation of macrophages in the context of innate immunity and interferes with NOS pathway in infected macrophages probably as a reciprocal effect
Chen et al., Gen Comp Endocrinol 2012 : Utilizing the tissue samples and growth data collected from our two preceding researches in largemouth bass ( LMB ), we have investigated effects of dietary arginine ( Arg ) levels and carbohydrate-to-lipid ( CHO/LIP ) ratios on the GH, IGF-I and insulin expression in related tissues to find possible relationships between the nutrient intake, growth performance and transcript level ... Utilizing the tissue samples and growth data collected from our two preceding researches in largemouth bass ( LMB ), we have investigated effects of dietary arginine ( Arg ) levels and carbohydrate-to-lipid ( CHO/LIP ) ratios on the GH, IGF-I and insulin expression in related tissues to find possible relationships between the nutrient intake, growth performance and transcript level ... Hepatic IGF-I and pituitary GH mRNA levels were significantly up-regulated by lower dietary Arg levels from 1.94 % to 3.01 % and by higher levels from 2.76 % to 3.01 %, respectively, while Brockmann body ( BB ) -containing tissue insulin mRNA expression was not affected ... These findings indicate that in LMB dietary Arg levels and CHO/LIP ratios regulate differentially the endocrine system of GH, IGF-I and insulin at transcription level ; this system, in turn, plays a fundamental role in the regulation of the nutrient metabolism and somatic growth ; and that hepatic IGF-I mRNA abundance should be a more reliable index to assess growth and nutritional fitness than the others, at least in LMB ... These findings indicate that in LMB dietary Arg levels and CHO/LIP ratios regulate differentially the endocrine system of GH, IGF-I and insulin at transcription level ; this system, in turn, plays a fundamental role in the regulation of the nutrient metabolism and somatic growth ; and that hepatic IGF-I mRNA abundance should be a more reliable index to assess growth and nutritional fitness than the others, at least in LMB
Duguay et al., J Biol Chem 1995 : Extended IGF-I- ( 1-76 ) is produced by cleavage at Arg77 and requires both Arg74 ( P4 ) and Arg77 ( P1 ) ... Mature IGF-I- ( 1-70 ) is produced by cleavage at Arg71 and requires both Lys68 ( P4 ) and Arg71 ( P1 )