Gene interactions and pathways from curated databases and text-mining

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AR — STAT3

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: AR → STAT3 (directlyIncreases, STAT3 Activity, AR Activity) Ueda et al., J Biol Chem 2002*
    Evidence: Immunoprecipitation and transactivation studies showed a direct interaction between amino acids 234-558 of the AR NTD and STAT3 following IL-6 treatment of LNCaP cells. These results demonstrate that activation of the human AR NTD by IL-6 was mediated through MAPK and STAT3 signal transduction pathways in LNCaP prostate cancer cells.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *