Gene interactions and pathways from curated databases and text-mining

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AR — IGF2

Text-mined interactions from Literome

Gnanapragasam et al., BJU Int 2000 (Prostatic Hyperplasia) : To determine the effect of insulin-like growth factor (IGF)-II on androgen receptor (AR) expression in prostate tissue, as IGFs may be important in re-activating androgen regulated genes in advanced prostate cancer because they can trans-activate the AR in the absence of ligand
Wu et al., Clin Cancer Res 2005 (Prostatic Neoplasms) : Our findings also suggest an IGF-IR dependent activity of the androgen receptor in androgen independent prostate cancer cells
Schayek et al., Clin Cancer Res 2009 (Prostatic Neoplasms) : Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor ( IGF-IR ) gene transcription in an androgen receptor dependent manner
Chi et al., Clin Cancer Res 2012 (Disease Progression...) : PSA declines in treatment-naive patients were observed, potentially mediated by IGF-IR effects on androgen receptor expression