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AKT1 — AR
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
AKT1
—
AR
(experimental interaction detection)
Lin et al., Proc Natl Acad Sci U S A 2001*
-
IRef Bind_translation Interaction:
AKT1
—
AR
(coimmunoprecipitation)
Lin et al., Proc Natl Acad Sci U S A 2001*
-
IRef Bind_translation Interaction:
AKT1
—
AR
(coimmunoprecipitation)
Lin et al., Proc Natl Acad Sci U S A 2001*, Yang et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
AKT1
—
AR
(direct interaction, pull down)
Lin et al., Proc Natl Acad Sci U S A 2001*
-
IRef Biogrid Interaction:
AKT1
—
AR
(physical association, affinity chromatography technology)
Deep et al., Oncogene 2008*
-
IRef Biogrid Interaction:
AKT1
—
AR
(physical association, affinity chromatography technology)
Lin et al., Proc Natl Acad Sci U S A 2001*
-
MIPS CORUM AR-AKT-APPL complex:
AR-AKT-APPL complex complex (AKT1-APPL1-AR)
Yang et al., J Biol Chem 2003*
-
IRef Corum Interaction:
Complex of AR-AKT1-APPL1
(association, anti tag coimmunoprecipitation)
Yang et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
AR
—
AKT1
(in vivo)
Wen et al., Cancer Res 2000*, Lin et al., Proc Natl Acad Sci U S A 2001*, Taneja et al., J Biol Chem 2005*
-
IRef Hprd Interaction:
AR
—
AKT1
(in vitro)
Wen et al., Cancer Res 2000*, Lin et al., Proc Natl Acad Sci U S A 2001*, Taneja et al., J Biol Chem 2005*
-
IRef Innatedb Interaction:
AR
—
AKT1
(unknown, -)
Lin et al., Proc Natl Acad Sci U S A 2001*
-
IRef Ophid Interaction:
AR
—
AKT1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Solit et al., Clin Cancer Res 2002
(Prostatic Neoplasms) :
Because mutations in the
androgen receptor (AR) and
activation of HER2 and
Akt may account, in part, for prostate cancer progression after castration or treatment with antiandrogens, we sought to determine whether an inhibitor of Hsp90 function could degrade these Hsp90 client proteins and inhibit the growth of prostate cancer xenografts with an acceptable therapeutic index
Kang et al., J Bone Miner Res 2004
:
This suggests that nongenomic androgen activation of
Akt is
mediated by
androgen receptor in osteoblasts
Ghosh et al., Endocr Relat Cancer 2005
(Neoplasms, Hormone-Dependent...) :
Akt regulates the expression and activation of the
androgen receptor
Lu et al., Int J Oncol 2006
(Prostatic Neoplasms) :
The purpose of this study is to investigate the
role of
PI3K-Akt signaling in prostate cancer cell growth and
androgen receptor (AR) mediated gene expression
Papadopoulou et al., Molecular cancer 2008
(Prostatic Neoplasms) :
Membrane
androgen receptor activation
triggers down-regulation of
PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells
Hong et al., Exp Cell Res 2013
(MAP Kinase Signaling System...) :
Our results also demonstrate that
AKT regulates
androgen receptor levels partly via the Raf/MEK/ERK pathway