Gene interactions and pathways from curated databases and text-mining

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APOE — MAPK6

Text-mined interactions from Literome

Ho et al., J Biol Chem 2001 (MAP Kinase Signaling System) : Further analyses demonstrated that exogenous and endogenous apoE prevented activation of MAPK but not induction of c-fos expression in response to serum growth factors
Maezawa et al., Journal of neuroinflammation 2006 : Our results suggest that LPS activation of innate immune response in TR APOE glia results in opposing outcomes from microglia and astrocytes as a result of TR APOE dependent activation of p38MAPK or NF-kappaB signaling in these two cell types
Liu et al., Journal of neuroinflammation 2011 (Inflammation) : Inhibitors of MAPK-p38 , ERK, and JNK inhibited ApoE induction by all these agents except glutamate, which was sensitive only to inhibitors of ERK and JNK
Kim et al., Exp Cell Res 2013 : While ApoE did not affect the activation of ERK, JNK, and p38 MAPK signaling pathways by RANKL, the phosphorylation of p65 trans-activation domain on serine 536 and transcription activity of NF-?B were reduced by ApoE overexpression