Gene interactions and pathways from curated databases and text-mining

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AKT1 — APOE

Text-mined interactions from Literome

Laffont et al., Biochem Biophys Res Commun 2002 : ApoE can induce Akt/protein kinase B phosphorylation in Neuro-2a via two different pathways
Cedazo-Mínguez et al., J Neurochem 2003 (Neuroblastoma) : ApoE4 also activated PKC-alpha and PKB possibly giving the subsequent GSK-3beta inhibition
Shen et al., Physiol Behav 2011 : Specifically, apoE induced the phosphorylation of Akt, peaking at 30 min, and the increased phosphorylation of Akt was significantly attenuated after pretreatment with LY294002 ( 50 µM ), an inhibitor of the PI3K signaling pathway