Gene interactions and pathways from curated databases and text-mining

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APC — CASP7

Text-mined interactions from Literome

Chen et al., Cancer Res 2003 (Colonic Neoplasms) : Regulation of caspase expression and apoptosis by adenomatous polyposis coli
Kumar et al., J Cell Mol Med 2008 (Coronary Disease) : APC significantly reduced the rate of apoptosis ( 14.2 +/- 1.3 % ) and caspase-3 activity
Guo et al., Eur J Neurosci 2009 (Anoxia...) : In neurons and BECs, 3K3A-APC blocked caspase-9 and -3 activation and induction of p53, and decreased the Bax/Bcl-2 pro-apoptotic ratio
Lu et al., Am J Physiol Heart Circ Physiol 2009 (Myocardial Reperfusion Injury) : In addition to functional protection following I/R, APC resulted in lower release of cytochrome c and caspase-3 degradation
Gorbacheva et al., Neurochem Int 2013 : To elucidate the NF-?B dependent and -independent mechanisms in the APC mediated cell survival, we analyzed in cortical and hippocampal neurons the effects of helenalin, a specific inhibitor of NF-?B activity, and APC on neuronal cell death and on the level of nuclear AIF, p53, caspase-3 and the apoptotic index ( Bax/Bcl-2 ratio ) ... However, APC , but not helenalin, reduced the glutamate induced activation of caspase-3