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ANXA6 — IL12A

Text-mined interactions from Literome

Mullins et al., J Immunol 1999 (Sarcoma, Experimental) : In contrast, paclitaxel significantly enhanced both normal host and TBH Mphi IL-12 p70 production in vitro, although TBH Mphi IL-12 production was lower than that of similarly treated normal host Mphis
Campbell et al., Eur J Immunol 2000 : IFN-gamma priming augmented Gal-lectin induced IL-12 mRNA expression independent of TNF-alpha and IL-1beta, and was required for IL-12 p70 protein production from macrophages and human peripheral blood mononuclear cells
Schmitt et al., J Immunol 2000 : We suggest that by suppressing DC/Mphi IL-12p70 secretion while promoting IL-12p40 homodimer secretion, UV exposure preferentially suppress the activation of Th1 cells, thereby suppressing Th-1 cell-driven inflammatory immune reactions
Walter et al., J Exp Med 2001 (Asthma...) : Epithelial IL-12 was also inducible during paramyxoviral bronchitis, but in this case, initial IL-12 p70 expression was followed by 75-fold greater expression of IL-12 p40 ( as monomer and homodimer )
Grumont et al., J Exp Med 2001 : Here we show that in CD8 ( + ) dendritic cells, major producers of IL-12 p70 , the Rel/nuclear factor (NF)-kappaB signaling pathway is necessary for the induction of IL-12 in response to microbial stimuli
Taoufik et al., Eur J Immunol 2001 : IL-12p70 and, more effectively, the combination of IL-12p70 and IFN-gamma, induced IL-12p40 mRNA expression and bioactive IL-12p70 production
Heystek et al., Clin Immunol 2003 : We demonstrate that IFNalpha/beta enhance IL-12p70 production by immature DCs but inhibit IL-12p70 production by mature DCs
Khan et al., Blood 2006 : We now provide evidence that hydrogen peroxide ( H2O2 ), a major component of ROSs, inhibits interleukin-12 (IL-12) p40 and IL-12 p70 induction in murine macrophages and catalase pretreatment prevents H2O2 mediated down-regulation of IL-12
Mahieu et al., Pediatr Crit Care Med 2005 (Respiratory Insufficiency) : Pathogen induced excessive production of the proinflammatory cytokine TNF-alpha and lack of antibacterial IL-12 p 70 response in the TA are associated with increased neonatal mortality among ventilated preterm infants
Yanagihori et al., J Invest Dermatol 2006 (Behcet Syndrome...) : As assessed by semiquantitative reverse transcription-PCR and ELISA, stimulation with Streptococcal antigens specifically increased expression of IL-12 p40 mRNA and protein, in conjunction with IL-12 p70 induction , in peripheral blood mononuclear cells from heterozygous patients
Oishi et al., Cytokine 2006 : The rhG-CSF induced a pre-PHx downregulation of the IL-12p70 protein levels, while also promoting the post-PHx reduction of the protein levels of IL-12p70 and IFN-gamma
Olleros et al., Immunology 2007 (Granuloma...) : Interleukin (IL)-12p40 , a subunit of IL-12p70 and IL-23, has previously been shown to inhibit IL-12p70 activity and interferon-gamma (IFN-gamma) production
Hensler et al., J Gen Virol 2009 : We detected expression of interleukin (IL)-6, tumour necrosis factor (TNF)-alpha, macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, RANTES and IL-12p40 from 2 to 6 h post-infection, and these peaked by 15-24 h. Expression of these factors decreased 24-48 h post-infection, with the exception of TNF-alpha which remained high throughout the entire 72 h. Interestingly, while IL-12p40 expression increased post-infection, bioactive IL-12p70 was not detected in the supernatants
Jana et al., Glia 2009 (MAP Kinase Signaling System) : This study was undertaken to investigate underlying mechanisms required for IL-12 p40 ( 2 ) - and IL-12 p70 induced expression of iNOS in microglia ... In contrast, both IL-12R beta 1 and IL-12R beta 2 were involved for IL-12 p70 induced microglial expression of iNOS
Gulliver et al., Am J Respir Cell Mol Biol 2011 (Asthma) : The B(1)R agonist Lda-BK was not chemotactic for hMo-DCs matured using LPS, TNF-a + IL-1ß, or CD40 ligand, but Lda-BK enhanced the secretion of IL-12p70 and inhibited the secretion of IL-12p40 by mature hMo-DCs
McBerry et al., J Immunol 2012 (Disease Models, Animal...) : p38 MAPK activation and IL-12p70 production was more robust from TFF2 ( -/- ) CD8+ DC compared with WT CD8+ DC and treatment of WT DC with rTFF2 suppressed TLR induced IL-12/23p40 production
Fowler et al., Immunol Cell Biol 2013 : We found that Vd2 cells are indirectly activated by BCG in an interleukin (IL)-12p70 dependent manner, and that DC production of the IL-12p70 responsible for Vd2 cell activation requires Toll-like receptor 2/4 ligands from BCG and interferon ( IFN ) -? from memory CD4 T cells
Heinzel et al., J Immunol 1996 (Endotoxemia) : Pretreatment of IFN-gamma 0/0 mice with recombinant mouse IFN-gamma ( rIFN-gamma ) enhanced circulating TNF-alpha by as much as sixfold, but serum IL-12 p40 and IL-12 p70 responses increased by only twofold or less
von Stebut et al., J Exp Med 1998 (Leishmaniasis, Cutaneous) : Parasite internalization was associated with activation manifested by upregulation of major histocompatibility complex ( MHC ) class I and II surface antigens, increased expression of costimulatory molecules ( CD40, CD54, CD80, and CD86 ), and interleukin (IL)-12 p40 release within 18 h. L. major induced IL-12 p70 release by DC required interferon gamma and prolonged ( 72 h ) incubation
Isler et al., Am J Respir Cell Mol Biol 1999 : However, IL-12 p70 was released when the autocrine production of IL-10 was neutralized by IL-10 blocking antibody, and IL-12 p40 production increased