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ANP32A — PPP2CA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Habrukowich et al., J Biol Chem 2010
:
Suppression of
ANP32A with siRNA
enhanced basal and DMS activated
PP2A activity suggesting that the sphingoid base binds to and relieves the inhibitory action of ANP32A on the PP2A complex ... Indeed, DMS relieved the
ANP32A mediated inhibition of
PP2A enzyme complex in vitro
Sánchez et al., Hum Mol Genet 2013
(Spinocerebellar Ataxias) :
We previously showed that the mutant ataxin-1 interacts with
Anp32a , a potent and selective
PP2A inhibitor , suggesting a role of PP2A in SCA1 ... In contrast, mutant Atxn1 induces a decrease in Y307-phosphorylation in Pp2a-c, known to enhance its activity, while reducing
Pp2a-b expression and
inhibiting Anp32a levels