◀ Back to IGF2
ANGPT2 — IGF2
Text-mined interactions from Literome
Phelps et al., Am J Physiol Cell Physiol 2006
:
Transcriptional and posttranscriptional regulation of
angiopoietin-2 expression
mediated by
IGF and PDGF in vascular smooth muscle cells
Ma et al., Endocrinology 2006
(MAP Kinase Signaling System) :
To determine how
Ang II transcriptionally
regulates IGF-IR expression in VSMCs, we generated 5'-end deletions of the IGF-IR promoter and measured Ang II-induced promoter-luciferase activity in VSMCs. Activities from these promoter sequences suggested that the Ang II-responsive region is located between -270 and -135 of the IGF-IR promoter ... Our results indicate that the mechanism by which
Ang II stimulates
IGF-IR expression in VSMCs involves NF-kappaB binding to NF-kappaB sites in the IGF-IR promoter, leading to expression of IGF-IR through both Ras/MAPK kinase 1-and inhibitory-kappaB kinase dependent pathways
Chu et al., J Cell Physiol 2012
(Cardiomegaly...) :
Histone acetylation is essential for
ANG-II induced
IGF-IIR gene expression in H9c2 cardiomyoblast cells and pathologically hypertensive rat heart