Gene interactions and pathways from curated databases and text-mining

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ANGPT2 — IGF2

Text-mined interactions from Literome

Phelps et al., Am J Physiol Cell Physiol 2006 : Transcriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells
Ma et al., Endocrinology 2006 (MAP Kinase Signaling System) : To determine how Ang II transcriptionally regulates IGF-IR expression in VSMCs, we generated 5'-end deletions of the IGF-IR promoter and measured Ang II-induced promoter-luciferase activity in VSMCs. Activities from these promoter sequences suggested that the Ang II-responsive region is located between -270 and -135 of the IGF-IR promoter ... Our results indicate that the mechanism by which Ang II stimulates IGF-IR expression in VSMCs involves NF-kappaB binding to NF-kappaB sites in the IGF-IR promoter, leading to expression of IGF-IR through both Ras/MAPK kinase 1-and inhibitory-kappaB kinase dependent pathways
Chu et al., J Cell Physiol 2012 (Cardiomegaly...) : Histone acetylation is essential for ANG-II induced IGF-IIR gene expression in H9c2 cardiomyoblast cells and pathologically hypertensive rat heart