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ANGPT2 — HIF1A

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: ANGPT2 → HIF1A (increases, ANGPT2 Activity) Yamakawa et al., Circ Res 2003*
  Evidence: In primary human endothelial cells, hypoxia, desferrioxamine, or infection with Ad2/HIF-1alpha/VP16, an adenoviral vector encoding a constitutively stable hybrid form of HIF-1alpha, increased the mRNA and protein levels of VEGF, angiopoietin-2 (Ang-2), and angiopoietin-4 (Ang-4)
• WikiPathways Photodynamic therapy-induced HIF-1 survival signaling: ARNT/HIF1A → SERPINE1/EDN1/NOS2/PTGS2/ANGPT1/VEGFA/TGFB3/TGFA/EPO/ANGPT2 (activation)
  

Text-mined interactions from Literome

Richard et al., J Biol Chem 2000 : More interestingly, Angiotensin II (Ang II) , thrombin, platelet derived growth factor, and other hormones can also increase HIF-1alpha in VSMC to levels that are substantially more elevated than the hypoxic treatment
Yamakawa et al., American journal of physiology. Renal physiology 2004 (Adenocarcinoma, Clear Cell...) : In RPTE cells, angiopoietin-4 (Ang-4) expression was selectively induced by hypoxia or by expression of a hybrid form of HIF-1alpha
Wolf et al., Antioxid Redox Signal 2005 (Anoxia...) : ANG II induces HIF-1alpha by a posttranscriptional mechanism suggesting that SM20 down-regulation leads to stabilization of HIF-1
Abaci et al., Am J Physiol Cell Physiol 2010 : Corresponding upregulation of VEGF, ANGPT2 , and GLUT-1 was observed in response to HIF-1alpha accumulation, whereas upregulation of ANGPT1 was detected only in hESCs and iPSCs