Gene interactions and pathways from curated databases and text-mining

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AKT1 — ANGPT2

Text-mined interactions from Literome

Gorin et al., FASEB J 2001 : We investigated the effect of Ang II on Akt/PKB activity in MCs ... Activation of Akt/PKB by Ang II was not abrogated by the PI3-K inhibitors or by the introduction of a dominant negative PI3-K, indicating that in MCs, PI3-K is not an upstream mediator of Akt/PKB activation by Ang II
Yang et al., Am J Physiol Regul Integr Comp Physiol 2002 : ANG II activation of the ANG II type 1 receptor caused increases in PKB activity, cellular GAP-43 levels, and neurite extension in a time- and dose dependent manner ... Depletion of PKB by specific antisense oligonucleotides attenuated ANG II stimulation of both GAP-43 and neurite extension
Motley et al., Hypertension 2003 : By immunoblotting with a phospho-specific antibody for Akt, we found that Ang II inhibits insulin induced Akt phosphorylation in a time- and concentration dependent manner
Benndorf et al., Circ Res 2003 : We therefore investigated the effect of Ang II on VEGF induced Akt and eNOS phosphorylation
Chiu et al., Am J Physiol Gastrointest Liver Physiol 2005 : To elucidate the downstream targets of EGFR, we demonstrated that ANG II stimulated phosphorylation of Akt at Ser473, mTOR at Ser2448, p70S6K1 at Thr389, and S6 ribosomal protein at Ser ( 235/236 )
Izawa et al., Exp Cell Res 2005 (Hypertension...) : Ang II inhibition of insulin stimulated IRS-1 tyrosyl phophorylation and Akt activation were reversed by PD98059 but not by SP600125
Li et al., Am J Physiol Heart Circ Physiol 2005 (Carotid Artery Injuries) : In cultured vascular smooth muscle cells, ANG II activates Akt through cytosolic phospholipase A2 (cPLA2) dependent phospholipase D2 (PLD2)
Benkirane et al., Am J Physiol Heart Circ Physiol 2006 : 15d-PGJ2 and rosiglitazone decreased ERK 1/2 and Akt peak activity, both of which were induced by ANG II via the AT1 receptor
Hingtgen et al., Physiol Genomics 2006 (Hypertrophy) : Finally, ANG II caused a time dependent increase in Akt activity via activation of AT(1) receptors, and this response was abolished by Ad-mediated expression of cytosolic human O2-* dismutase ( AdCu/ZnSOD )
Foo et al., J Cell Physiol 2006 (Hypertrophy) : Adenoviral overexpression of HO-1 was accompanied by a significant increase in Ang II induced phosphorylation of Akt , however, Ang II-mediated p38 mitogen activated protein kinase ( MAPK ) phosphorylation was attenuated
Daly et al., Proc Natl Acad Sci U S A 2006 : In addition, we show that Ang-2 , like Ang-1, activates Tie2/Akt signaling in vivo, thereby inhibiting the expression of FOXO1 target genes
Niu et al., Cancer Res 2007 (Breast Neoplasms...) : Consistent with the important roles of AKT and mitogen activated protein kinase in the HER2 signaling pathway, AKT and ERK mitogen activated protein kinase ( MAPK ) kinase activity is necessary for Ang-2 up-regulation by HER2
Kou et al., Vascul Pharmacol 2007 : Low concentration Ang II caused a dose dependent increase in Akt phosphorylation, while high concentration of Ang II led to a decrease of Akt phosphorylation
Zhong et al., Br J Pharmacol 2008 (Insulin Resistance) : In addition, Ang II diminished insulin stimulated phosphorylation of Akt ( at Ser ( 473 ) ) and eNOS ( at Ser ( 1177 ) ) and NO generation, effects which were reversed by ACE2 gene transfer and anti-MIF treatment in endothelial cells
Zhao et al., Acta Biochim Biophys Sin (Shanghai) 2008 (Breast Neoplasms) : Ang II significantly reduced the ratio of apoptotic cells and stimulation of phospho-Akt-Thr308 and phospho-Akt-Ser473 in a dose dependent and time dependent manner
Tabet et al., Circ Res 2008 (Hypertension) : Ang II stimulation increased activation of ERK1/2, p38MAPK, and AKT , with enhanced effects in SHR. SHP-2 knockdown resulted in increased AKT phosphorylation, without effect on ERK1/2 or p38MAPK
Chiou et al., Evidence-based complementary and alternative medicine : eCAM 2011 : Western blot analysis revealed Ang II increased the phosphorylation levels of Akt and mitogen activated protein kinases ( MAPKs ; p38, ERK1/2 and JNK ) in rVSMC ... Also, the CQC pretreatment markedly suppressed Ang-II induced phosphorylation of Akt and JNK rather than ERK1/2, although it failed to affect p38 phosphorylation
Wang et al., Diabetologia 2010 (Diabetes Mellitus, Experimental...) : Oxidative stress and formation of AGEs were assessed by immunoblotting, expression of Ang-2 ( also known as Angpt2 ) by RT-PCR, activation of protein kinase B ( AKT ) and heat shock protein (HSP)-27 levels by immunofluorescence, and incipient retinal vascular changes by quantitative morphometry of retinal digest preparations ... Oxidative stress and formation of AGEs were assessed by immunoblotting, expression of Ang-2 ( also known as Angpt2 ) by RT-PCR, activation of protein kinase B ( AKT ) and heat shock protein (HSP)-27 levels by immunofluorescence, and incipient retinal vascular changes by quantitative morphometry of retinal digest preparations
Liu et al., Zhonghua Zheng Xing Wai Ke Za Zhi 2010 (Cicatrix, Hypertrophic) : Ang II increased Akt phosphorylation and PI3K activity in cultured hypertrophic scar fibroblasts in a dose- and time dependent manner
Zhao et al., J Cell Physiol 2010 (Breast Neoplasms) : In addition, Ang II caused rapid activation of p-Akt in a dose- and time dependent manner
Schreiner et al., Cardiovasc Res 2011 : Since NADPH oxidases (Nox) 1 and 4 are major ROS sources in VSMCs, we examined their need for Akt phosphorylation in response to Ang II or EGF
Hua et al., American journal of physiology. Renal physiology 2012 : In these studies, we determined that ANG II induces phosphorylation of ETS-1 via activation of the type 1 ANG II receptor and that Erk1/2 and Akt/PKB phosphorylation are required for these effects
Chao et al., PloS one 2013 : Furthermore, Ang II stimulated ERK and Akt phosphorylation in NSCs. Pretreatment of MEK inhibitor, but not PI3K inhibitor, inhibited Ang II-induced ERK phosphorylation as well as cell proliferation