Gene interactions and pathways from curated databases and text-mining

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ANG — NOS1

Text-mined interactions from Literome

Schultz et al., Am J Physiol Heart Circ Physiol 2002 (Arrhythmias, Cardiac...) : LV angiotensin II (ANG II) levels were increased ( 68 +/- 12 vs. 20 +/- 5 pg/g, P < 0.01 ) as steady-state ANG II type 1 ( AT(1) ) receptor mRNA was decreased 40 % and endothelial nitric oxide synthase mRNA levels were increased 2.5-fold in PO versus control dogs ( P < 0.05 )
Uhlenius et al., J Renin Angiotensin Aldosterone Syst 2001 (Albuminuria...) : To investigate the changes in the angiotensin II (Ang II) receptors and nitric oxide ( NO ) -cGMP pathway in the rat kidney after nitric oxide synthase ( NOS ) blockade
Andersen et al., Am J Physiol Regul Integr Comp Physiol 2002 : Plasma ANG II increased greater than sevenfold with AT(1) blockade and doubled with NOS inhibition ( paired t-test, P < 0.05 ), whereas it decreased by 50-80 % during volume expansion irrespective of pretreatment, i.e., during NOS inhibition, volume expansion did not generate subnormal plasma ANG II concentrations. In conclusion, 1 ) acute AT(1) blockade leads to hyperfiltration, natriuresis, and hyperresponsiveness to volume expansion, 2 ) these responses are > 85 % inhibitable by unspecific NOS inhibition, and 3 ) NOS inhibition alone is followed by increases in plasma ANG II, hypofiltration, and severe antinatriuresis that may be counterbalanced but not overwhelmed by volume expansion
Bravo et al., Kidney Int Suppl 2003 : Ang II infusion and NOS inhibition induce tubular injury with epithelial cell transdifferentiation and expression of stress proteins
Deng et al., Kidney Int 2005 : Glomerular hemodynamic and reabsorptive consequences of NOS inhibition require angiotensin II (Ang II) , implying an antagonistic relationship between nitric oxide and Ang II
Costa et al., Am J Physiol Heart Circ Physiol 2010 (Disease Models, Animal...) : It has been shown that angiotensin (ANG)- ( 1-7 ) activates nitric oxide synthase (NOS) in isolated ventricular myocytes from normotensive rats ... Since many ANG- ( 1-7 ) actions are enhanced in situations of increased ANG II activity, as in hypertension, in this study we investigated the in vivo effect of ANG- ( 1-7 ) on NOS activity and expression of endothelial ( eNOS ), neuronal ( nNOS ), and inducible NOS (iNOS) in ventricles from spontaneously hypertensive rats ( SHR ) ... Ventricular eNOS and nNOS expression were increased 67.4 ± 6.4 and 51 ± 10 %, respectively, by ANG- ( 1-7 ), whereas iNOS was not changed ... Our results show that in rats in a hypertensive state, ANG- ( 1-7 ) infusion upregulates cardiac NOS expression and activity through an AT(2)- and bradykinin dependent mechanism
Yanagisawa et al., Toxicol Appl Pharmacol 1998 (Acute Kidney Injury...) : To elucidate the mechanisms underlying the development of HgCl2 induced acute renal failure ( ARF ), we examined the expression of endothelin (ET)-1, endothelial ( e ) nitric oxide synthase (NOS) and inducible ( i) NOS , and a role of angiotensin II (ANG II) and tumor necrosis factor (TNF) in glomeruli and cortices from rats at 20 h after exposure of HgCl2. Prepro-ET-1 and iNOS mRNA were significantly increased in glomeruli and cortices from rats with HgCl2 induced ARF