Gene interactions and pathways from curated databases and text-mining

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ANG — MAPK14

Text-mined interactions from Literome

Morrell et al., Am J Physiol 1999 : In addition, ANG II led to rapid activation of mitogen activated protein kinase ( MAPK ), and ANG II-stimulated DNA synthesis was inhibited by the specific inhibitor of MAPK PD-98059
Otani et al., Diabetes 2001 : Protein kinase C ( PKC ) inhibitor completely inhibited AII induced Ang2 expression, and the mitogen activated protein kinase ( MAPK ) inhibitor also inhibited it by 69.4+/-15.6 %
He et al., Sheng Li Xue Bao 1998 (Cardiomegaly...) : MAPK may be involved in the progress of cardiac hypetrophy in SHR and the increased MAPK activity may be partly induced by Ang II
Zimpelmann et al., American journal of physiology. Renal physiology 2001 : ANG II ( 10 ( -7 ) M ) significantly inhibited mitogen activated protein kinase ( MAPK ) activity in transfected cells, associated with decreased phosphorylation of the extracellular signal related kinases ERK1 and ERK2
Wei et al., J Renin Angiotensin Aldosterone Syst 2000 : The role of angiotensin II (Ang II)-receptors on mitogen activated protein kinase ( MAPK ) activation in cardiomyocytes remains controversial
Kim et al., FASEB J 2002 (MAP Kinase Signaling System) : This study examined the effect of ephrinB2 induced activation of EphB kinases on vascular endothelial growth factor ( VEGF ) - and angiopoietin-1 (Ang1) induced Ras/mitogen activated protein kinase ( MAPK ) signaling cascades in human umbilical vein endothelial cells ( HUVECs ) ... Accordingly, ephrinB2 inhibited VEGF- and Ang1 induced Ras-MAPK activities, whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation
Sharma et al., Mol Cell Biochem 2002 : Angiotensin II (ANG II) and platelet derived growth factor ( PDGF ) stimulated the immunoreactive Erk2 and p38MAPK activities and their protein levels by 2-4 fold
Espiritu et al., American journal of physiology. Renal physiology 2002 (Acidosis) : Regulation of renal Na-HCO cotransporter ( NBC1 ) activity by cholinergic agonists, ANG II, and acute acidosis ( CO ( 2 ) ) requires both Src family kinase (SFK) and classic MAPK pathway activation
Natarajan et al., Endocrine 2002 : To evaluate the role of MAPK activation in ANG II and the effects of LO on aldosterone synthesis, experiments were performed using the human adrenocortical cell line H295R, which secretes aldosterone in response to ANG II
Weng et al., Alcohol 2003 : We have demonstrated previously that 24 h of ethanol treatment potentiates angiotensin II (ANG II) stimulated p42/p44 mitogen activated protein kinase ( MAPK ) activity in hepatocytes
Yoon et al., Biochem Biophys Res Commun 2003 : Our results indicate that : ( 1 ) caveolae may be the platform for Tie2/PLD association in endothelial cells ; ( 2 ) PLD is a new mediator of Ang1/Tie2 induced signaling pathway, and it participates in MAPK activation and endothelial cell migration
Tallant et al., Hypertension 2003 : Finally, Ang- ( 1-7 ) inhibited Ang II stimulation of mitogen activated protein kinase activities ( ERK1/2 )
Han et al., American journal of physiology. Renal physiology 2004 : Indeed, ANG II increased p44/42 MAPK activity
Lai et al., Beijing Da Xue Xue Bao 2004 : ANG II promoted podocyte apoptosis in a time- and dose dependent manner ; ANG II stimulated p38MAPK , but inhibited JNK ; SB202190 inhibited both ANG II-induced podocyte apoptosis and p38MAPK phosphorylation ; Inhibition of ERK by PD98059 had no effect on ANG II-induced cell apoptosis
Kanda et al., Cancer Res 2005 : Ang1 activated mitogen activated protein kinase ( MAPK ) and phosphoinositide 3-kinase (PI3K) in IBE cells and HUVECs
Chan et al., Circ Res 2005 : These results suggest that NADPH oxidase derived O2*- underlies the activation of p38 MAPK or ERK1/2 by Ang II in the ventrolateral medulla
Cain et al., Med Sci Monit 2006 (MAP Kinase Signaling System) : Ethanol exacerbated cAMP production by several fold but inhibited MAPK activity and subsequent cell growth induced by Ang II
Su et al., Kidney Int 2006 : While incubation of proximal tubular cells with Ang- ( 1-7 ) alone did not significantly affect MAPK phosphorylation, Ang- ( 1-7 ) ( 10 ( -7 ) M ) completely inhibited Ang II-stimulated phosphorylation of p38, ERK 1/2, and JNK ... In summary, Ang- ( 1-7 ) inhibits Ang II-stimulated MAPK phosphorylation in proximal tubular cells
Godeny et al., Am J Physiol Cell Physiol 2006 : High-affinity binding of angiotensin II (ANG II) to the ANG II type 1 receptor ( AT(1)R ) results in the activation of ERK1/2 mitogen activated protein kinases ( MAPK )
Guo et al., Peptides 2006 (MAP Kinase Signaling System) : Furthermore, AT(1) is required for p38MAPK phosphorylation induced by Ang II
Cetin et al., Pharmacology 2007 : Angiotensin II (Ang II) induces a rapid increase in mitogen activated protein kinase ( MAPK ) activity through the Ang II type 1 receptor in cultured rat vascular smooth muscle cells ( VSMCs )
Yuan et al., FASEB J 2007 : Ang1 mediated AKT and 42/44MAPK phosphorylation is predominantly Tie2 mediated, and Tie1 down-regulates this pathway
Bao et al., J Cardiovasc Pharmacol 2007 (Hypertension...) : Angiotensin II (Ang II) activates p38 mitogen activated protein kinase ( p38 MAPK ) and increases reactive oxygen species ( ROS ), but the nature of the relationship in vivo is not fully understood
Louis et al., Am J Physiol Heart Circ Physiol 2007 (Hypertrophy...) : ANG II did not induce SMC hypertrophy or phosphorylation of p38 MAPK and FAK in alpha ( 1 ) ( -/- ) mice ... These results emphasize the importance of alpha(1)beta(1)-integrin in p38 MAPK and FAK phosphorylation during vascular hypertrophy in response to ANG II
Zhang et al., Cardiovasc Res 2007 : In this review, we discuss the possible mechanisms of Ang II-induced cardiac pharmacological preconditioning ( PC ), and focus on the role of mitochondrial K ( ATP ) channels, mitochondrial ROS production, and MAPK activation in response to Ang II stimulation
Wei et al., Hypertension 2008 (Acute Disease...) : We reported recently that Ang II stimulates mitogen activated protein kinase ( MAPK ) to upregulate brain angiotensin type 1 receptors in HF rats
Zimpelmann et al., American journal of physiology. Renal physiology 2009 (MAP Kinase Signaling System) : These data indicate that Ang- ( 1-7 ) activates MAPK phosphorylation via binding to a specific receptor in human mesangial cells ... Stimulation of p38 MAPK phosphorylation by Ang- ( 1-7 ) leads to release of arachidonic acid and production of TGF-beta1 and extracellular matrix proteins
Gava et al., Nephrol Dial Transplant 2009 (Diabetic Nephropathies) : These data indicate that in proximal tubular cells, binding of Ang- ( 1-7 ) to the receptor Mas stimulates SHP-1, associated with the inhibition of glucose stimulated p38 MAPK
Chen et al., Neurosci Res 2009 (MAP Kinase Signaling System) : Downstream of beta1-integrin, Ang1 stimulation led to a approximately 2.6 fold increase in focal adhesion kinase ( FAK ) phosphorylation and no change in the activation of mitogen activated protein kinase ( MAPK ) nor c-Jun N-terminal kinase (JNK)
Aroor et al., Alcohol 2009 : Ethanol treatment potentiated nuclear activation of p42/44 MAPK by Ang II but not translocation of p42/44 MAPK protein
Rabkin et al., J Heart Valve Dis 2009 : In response to Ang II ( 1 microM ), MAPK phosphorylation levels were increased by 3.5-fold after 15 min, peaked at 4.6-fold after 60 min, and decreased to 1.9-fold greater than control after 120 min of treatment ... p38 MAPK is present in VICs, and is activated by Ang II
Ketsawatsomkron et al., Vascul Pharmacol 2010 (Insulin Resistance) : Activation of p42/p44 MAPK ( a mitogenic pathway ) induced by insulin was further enhanced by Ang II
Zhang et al., Am J Physiol Heart Circ Physiol 2012 (MAP Kinase Signaling System) : Angiotensin II (ANG II) induced mitogen activated protein kinase ( MAPK ) signaling upregulates angiotensin II type-1 receptors ( AT(1)R ) in hypothalamic paraventricular nucleus ( PVN ) and contributes to AT(1)R mediated sympathetic excitation in heart failure
Eguchi et al., J Biol Chem 1996 : These data suggest that Ang II-induced MAPK activation through the Ang II type 1 receptor could be mediated by p21(ras)activation through a currently unidentified tyrosine kinase that lies downstream of Gq-coupled Ca2+/calmodulin signals ... In cultured rat vascular smooth muscle cells, angiotensin II (Ang II) induced a rapid increase in mitogen activated protein kinase ( MAPK ) activity through the Ang II type 1 receptor, which was insensitive to pertussis toxin but was abolished by the phospholipase C inhibitor, U73122
Yang et al., J Neurosci 1996 : This demonstrates that induction of these genes requires mitogen activated protein kinase activation by Ang II
Takahashi et al., FEBS Lett 1996 : Angiotensin II (Ang II) , a potent hypertrophic factor for vascular smooth muscle cells ( VSMC ), induces activation of the ras proto-oncogene product ( Ras ) and mitogen activated protein ( MAP ) kinases , and tyrosine phosphorylation of a focal adhesion associated protein, paxillin
Takahashi et al., J Biol Chem 1997 : Angiotensin II (ANG II) , a potent hypertrophic factor of vascular smooth muscle cells ( VSMC ), induces activation of the ras protooncogene product ( Ras ) and mitogen activated protein ( MAP ) kinases and subsequent stimulation of protein synthesis in VSMC
Tian et al., Endocrinology 1998 : An analysis of the growth promoting pathways in cultured bovine adrenal glomerulosa cells revealed that Ang II, acting via the AT1 receptor, caused rapid but transient activation of mitogen activated protein kinase ( MAPK ), with an ED50 of 10-50 pM
Eguchi et al., J Biol Chem 1998 : We have recently reported that angiotensin II (Ang II) induced mitogen activated protein kinase ( MAPK ) activation is mainly mediated by Ca2+ dependent activation of a protein tyrosine kinase through Gq-coupled Ang II type 1 receptor in cultured rat vascular smooth muscle cells ( VSMC )
Muthalif et al., Proc Natl Acad Sci U S A 1998 : These data suggest that activation of MAPK by NE, Ang II, and EGF is mediated by a signaling mechanism involving 20-HETE, which is generated by stimulation of cPLA2 by CaMKII ... Norepinephrine ( NE ) and angiotensin II (Ang II) , by promoting extracellular Ca2+ influx, increase Ca2+/calmodulin dependent kinase II ( CaMKII ) activity, leading to activation of mitogen activated protein kinase ( MAPK ) and cytosolic phospholipase A2 (cPLA2), resulting in release of arachidonic acid ( AA ) for prostacyclin synthesis in rabbit vascular smooth muscle cells