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ANG — IGF1

Text-mined interactions from Literome

Brink et al., Hypertension 1999 (Hypertrophy, Left Ventricular) : In conclusion, autocrine upregulation of cardiac IGF-I and IGF-IR mRNA by Ang II occurs through hemodynamic and nonhemodynamic mechanisms, respectively, and may modulate cardiac structural changes that occur in hypertension
Serneri et al., Circ Res 2001 (Cardiomyopathy, Dilated...) : This study demonstrates that ( 1 ) the clinical course of HF is associated with progressive increase in cardiac Ang II formation, ( 2 ) AT(1) density does not change on failing myocytes, and ( 3 ) failing myocytes are unable to synthesize IGF-I and ET-1 in response to Ang II stimulation
Phelps et al., Am J Physiol Cell Physiol 2006 : In contrast, IGF-I , which did not significantly activate ERK or JNK, stimulated increased Ang2 expression through transcriptional activation