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AKT1 — AMPH
Text-mined interactions from Literome
Wei et al., Mol Pharmacol 2007
:
Here, we show in a heterologous expression system and in murine striatal synaptosomes that
AMPH causes a time dependent decrease in the activity of
Akt , a protein kinase immediately downstream of PI3K ... This effect was blocked by the DAT inhibitor cocaine, suggesting that
AMPH must interact with DAT to
inhibit Akt
Shi et al., J Neurochem 2007
:
These data implicate differential regulation of phospho-extracellular signal regulated kinase, phospho-cAMP response element binding protein versus
phospho-Akt in sensitized
responses to
AMPH
McGinty et al., J Neurochem 2008
:
In contrast, AMPH activates phosphoinositide-3 kinase substrates, like protein kinase B/Akt, only in the nuclei of striatal cells but this transient increase induced by
AMPH is
followed by a delayed decrease in
protein kinase B/Akt phosphorylation whether or not the rats have a drug history, suggesting that the phosphoinositide-3 kinase pathway is not essential for AMPH induced behavioral sensitization ... In contrast, AMPH activates phosphoinositide-3 kinase substrates, like protein kinase B/Akt, only in the nuclei of striatal cells but this transient increase induced by
AMPH is
followed by a delayed decrease in protein kinase
B/Akt phosphorylation whether or not the rats have a drug history, suggesting that the phosphoinositide-3 kinase pathway is not essential for AMPH induced behavioral sensitization
Zheng et al., Neuroreport 2013
:
Pretreatment of animals with lithium prevented an
AMPH induced decrease in striatal
p-Akt and p-FoxO1 levels