Gene interactions and pathways from curated databases and text-mining

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AKT1 — AMPH

Text-mined interactions from Literome

Wei et al., Mol Pharmacol 2007 : Here, we show in a heterologous expression system and in murine striatal synaptosomes that AMPH causes a time dependent decrease in the activity of Akt , a protein kinase immediately downstream of PI3K ... This effect was blocked by the DAT inhibitor cocaine, suggesting that AMPH must interact with DAT to inhibit Akt
Shi et al., J Neurochem 2007 : These data implicate differential regulation of phospho-extracellular signal regulated kinase, phospho-cAMP response element binding protein versus phospho-Akt in sensitized responses to AMPH
McGinty et al., J Neurochem 2008 : In contrast, AMPH activates phosphoinositide-3 kinase substrates, like protein kinase B/Akt, only in the nuclei of striatal cells but this transient increase induced by AMPH is followed by a delayed decrease in protein kinase B/Akt phosphorylation whether or not the rats have a drug history, suggesting that the phosphoinositide-3 kinase pathway is not essential for AMPH induced behavioral sensitization ... In contrast, AMPH activates phosphoinositide-3 kinase substrates, like protein kinase B/Akt, only in the nuclei of striatal cells but this transient increase induced by AMPH is followed by a delayed decrease in protein kinase B/Akt phosphorylation whether or not the rats have a drug history, suggesting that the phosphoinositide-3 kinase pathway is not essential for AMPH induced behavioral sensitization
Zheng et al., Neuroreport 2013 : Pretreatment of animals with lithium prevented an AMPH induced decrease in striatal p-Akt and p-FoxO1 levels