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ALPI — CASP7
Text-mined interactions from Literome
Wu et al., Nature 2000
:
In conjunction with other observations, our results reveal how Smac may relieve
IAP inhibition of
caspase-9 activity
Hawkins et al., Apoptosis 2001
:
Analysis of candidate antagonists of
IAP mediated
caspase inhibition using yeast reconstituted with the mammalian Apaf-1 activated apoptosis mechanism
Olson et al., J Biol Chem 2003
:
Disruption of
IAP mediated
caspase inhibition has been shown to be an important activity for pro-apoptotic proteins in Drosophila ( Reaper, HID, and Grim ) and in mammalian cells ( Smac/DIABLO and Omi/HtrA2 )
Silke et al., J Biol Chem 2004
:
Analysis of a Grim mutant that promoted XIAP degradation, but was not cytotoxic, suggests that Grim killing in transient assays is due to a combination of IAP depletion, blocking of
IAP mediated
caspase inhibition, and at least one other unidentified function
Geisbrecht et al., Cell 2004
:
A role for Drosophila
IAP1 mediated
caspase inhibition in Rac dependent cell migration
McEleny et al., BJU Int 2004
(Prostatic Neoplasms) :
CAPE is an effective inhibitor of NF-kappaB activation in PC-3 cells, but the mechanism of apoptosis, and the corresponding loss of
IAP expression, is
caspase dependent
Kikuchi et al., Gene 2008
:
GCN5 and BCR signalling collaborate to induce pre-mature B cell apoptosis through depletion of ICAD and
IAP2 and
activation of
caspase activities
Yang et al., Cell Biol Toxicol 2010
(Carcinoma, Hepatocellular...) :
The
caspase-3 activation was
inhibited by overexpressing Bcl-X ( L ) or
IAP2
Vandergaast et al., J Virol 2011
:
Elevation of
IAP levels by ectopic expression
repressed caspase activation
Manji et al., J Virol 1997
:
Op-iap prevented in vivo caspase mediated cleavage of the baculovirus substrate inhibitor P35 and
blocked caspase activity upon viral infection or UV irradiation