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ALOX5 — MAPK14

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: ALOX5 → MAPK14 (increases, MAPK14 Activity, ALOX5 Activity) Werz et al., Proc Natl Acad Sci U S A 2000*
  Evidence: Different agents activated the 5-LO kinase activities, including stimuli for cellular leukotriene biosynthesis (A23187, thapsigargin, N-formyl-leucyl-phenylalanine), compounds that up-regulate the capacity for leukotriene biosynthesis (phorbol 12-myristate 13-acetate, tumor necrosis factor alpha, granulocyte/macrophage colony-stimulating factor), and well known p38 stimuli as sodium arsenite and sorbitol. For all stimuli, 5-LO kinase activation was counteracted by SB203580 (3 microM or less), an...

Text-mined interactions from Literome

Werz et al., Blood 2002 : In contrast, stress induced product formation and translocation of 5-LO , as well as activation of p38 MAPK , occurred also after Ca ( ++ ) depletion
Ha et al., Exp Mol Med 2011 : We describe an alternative ROS production pathway that is triggered by CD40 ligation, involves 5-lipoxygenase (5-LO) , and results in activation of p38 MAPK