Cowburn et al., J Immunol 1999
(Asthma) :
We hypothesized that IL-5 induces the expression of 5-LO and/or its activating protein FLAP in eosinophils, and that this might be modulated by anti-inflammatory corticosteroids ... Neither IL-5 nor dexamethasone altered 5-LO expression, but IL-5 significantly increased 5-LO immunofluorescence localizing to eosinophil nuclei
Urasaki et al., J Leukoc Biol 2001
:
These findings suggest that IL-5 activates both cPLA2 and 5-LO but PAF activates only 5-LO Rainsford et al., J Pharm Pharmacol 1996
:
Effects of 5-lipoxygenase inhibitors on interleukin production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors