Gene interactions and pathways from curated databases and text-mining

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AKT1 — IRS4

Text-mined interactions from Literome

Uchida et al., Mol Cell Biol 2000 : IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis ... IRS-4 also promoted the activation of PKB/Akt and BAD phosphorylation during insulin stimulation ; however, it weakly bound or activated p85 associated PI 3-kinase and failed to mediate the activation of p70 ( s6k ) ... IRS-4 also promoted the activation of PKB/Akt and BAD phosphorylation during insulin stimulation ; however, it weakly bound or activated p85 associated PI 3-kinase and failed to mediate the activation of p70 ( s6k )
Shimwell et al., Oncogene 2009 (Cell Transformation, Viral) : Once expressed, as well as binding to E1A and the insulin receptor, IRS-4 remains tyrosine phosphorylated and constitutively associates with the regulatory p85 subunit of phosphoinositide 3 kinase, resulting in the phosphorylation of Akt ( causing activation ) and GSK-3beta ( causing inhibition )
Chai et al., J Neuroendocrinol 2013 : AGD3 binds with insulin receptor substrate 4 and increases insulin stimulated phospho-Akt and regulates AMP activated protein kinase and mammalian target of rapamycin downstream target S6 kinase phosphorylation