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AKT1 — IL22

Text-mined interactions from Literome

Brand et al., Am J Physiol Gastrointest Liver Physiol 2006 (Crohn Disease...) : IL-22 binding to its receptor complex activates STAT1/3, Akt , ERK1/2, and SAPK/JNK MAP kinases
Brand et al., Am J Physiol Gastrointest Liver Physiol 2007 (Disease Models, Animal...) : Binding of IL-22 to its receptor complex expressed on human hepatic cells and primary human hepatocytes resulted in the activation of MAPKs, Akt , and STAT proteins
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008 (Hyperglycemia) : Resveratrol inhibits high glucose induced PI3K/Akt/ERK dependent interleukin-17 expression in primary mouse cardiac fibroblasts
Doroshow et al., Biochem Pharmacol 2012 : Exposure of HT-29 colon cancer cells, which express Nox1, to DPI and DTI confirmed their inhibitory effects on steady state ROS levels, and demonstrated decreased Stat, Erk1/2, and Akt signaling mediated by IL-4, IL-6, IL-13, and IL-22 , possibly due to a concomitant increase in tumor cell phosphatase activity
Mitra et al., Cytokine 2012 (Arthritis...) : In NHEK and FLS, IL-22 significantly induced phosphorylation of Akt and mTOR which was effectively blocked by Rapamycin and NVP-BEZ235
Datta Mitra et al., J Invest Dermatol 2013 (Psoriasis) : Interestingly, BE inhibited the IL-22 induced gene expression of AKT1 , MTOR, chemokines [ IL-8 and RANTES ( regulated upon activation, normal T-cell expressed and secreted ) ], and psoriasin ( S100A7 ) more significantly than Vit-D