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AHR — IL5

Text-mined interactions from Literome

Mould et al., J Immunol 2000 (Bronchial Hyperreactivity...) : Gene transfer of IL-5 and/or eotaxin to the lungs of naive mice induced a pronounced and selective airways eosinophilia, but did not result in eosinophil degranulation or AHR
Matsumoto et al., Int Arch Allergy Immunol 2003 (Eosinophilia...) : Genetically IL-5-deficient mice lack antigen induced airway eosinophilia, but little is known about the role of IL-5 in accumulation and activation of CD4+ T cells in the lung and in airway hyperresponsiveness (AHR) ... We examined the role of IL-5 in CD4+ T cell activation, cytokine production, and AHR upon Asc sensitization
Yang et al., J Allergy Clin Immunol 2003 (Bronchial Hyperreactivity...) : Eotaxin-2 and IL-5 cooperatively promoted eosinophil accumulation, IL-13 production, and AHR to methacholine
Webb et al., Eur J Immunol 2003 (Bronchial Hyperreactivity...) : IL-4Ralpha/IL-5 ( -/- ) mice were significantly defective in their ability to produce IL-13 and failed to develop AHR, suggesting that IL-5 indirectly regulates AHR in allergic IL-4Ralpha ( -/- ) mice by an IL-13 dependent mechanism
Hall et al., Infect Immun 1998 (Asthma...) : Taken together, these data indicate that IL-5 and eosinophils are required for the induction of AHR by filarial helminths