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ADORA3 — MAPK14

Text-mined interactions from Literome

Robinson et al., Eur J Pharmacol 2001 : Furthermore, adenosine A(1) receptor mediated increases in p42/p44 MAPK were sensitive to the MAPK kinase 1 inhibitor PD 98059 ( 2'-amino-3'-methoxyflavone ), whereas p38 MAPK responses were blocked by the p38 MAPK inhibitor SB 203580 ( 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) 1H-imidazole ) ... Finally, adenosine A(1) receptor stimulation in DDT ( 1 ) MF-2 cells also activated p38 MAPK but not JNK via a pertussis toxin-sensitive pathway
Graham et al., Eur J Pharmacol 2001 : The high affinity adenosine A3 receptor agonist IB-MECA ( 1-deoxy-1- [ 6- [ [ ( 3-iodophenyl ) methyl ] amino ] -9H-purin-9-yl ] -N-methyl-beta-D-ribofuranuronamide ) stimulated time ( peak activation occurring after 5 min ) and concentration dependent ( pEC50=9.0+/-0.2 ) increases in p42/p44 MAPK in CHO-A3 cells ... In contrast, inhibition of protein kinase C had no significant effect on adenosine A3 receptor induced p42/p44 MAPK activation ... In conclusion, we have shown that the human adenosine A3 receptor stimulates p42/p44 MAPK and c-fos mediated luciferase gene expression in transfected CHO cells