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ADCYAP1 — CREB1

Text-mined interactions from Literome

Schomerus et al., Brain Res 1999 (Calcium Signaling) : VIP- and PACAP induced CREB phosphorylation is restricted to subpopulations of neonatal cells and thus also displays an adult pattern
von Gall et al., Neuroreport 2000 : As detected by immunohistochemistry in SCN slices from wild-type mice, melatonin completely blocked PACAP stimulated CREB phosphorylation at low concentrations ( 1 nM ) ... In Mel1a melatonin receptor-deficient mice, the PACAP induced CREB phosphorylation was inhibited only at melatonin concentrations of 100 nM
Deavall et al., Am J Physiol Gastrointest Liver Physiol 2000 (Neuroendocrine Tumors) : Electrophoretic mobility shift assay and supershift analysis revealed that CREB and not AP1 bound to the CRE/AP1 site and that PACAP increased the proportion of phosphorylated CREB that was bound
Delgado et al., J Biol Chem 2001 (MAP Kinase Signaling System) : Second, VIP/PACAP induce phosphorylation of the CRE binding protein ( CREB ) and its binding to the CREB binding protein (CBP)
Leceta et al., Ann N Y Acad Sci 2000 (Inflammation) : VIP/PACAP inhibit iNOS expression through reduction in NFkB and IRF-1 binding, and augment IL-10 by increasing CREB binding
Farini et al., Endocrinology 2003 (Prostatic Neoplasms) : Moreover, PACAP stimulates phosphory-lation and activation of the cAMP response element binding transcription factor ( CREB ), and MAPK activation is necessary for its full transcriptional activity, indicating a direct involvement of cAMP response element in PACAP action
Nagashima et al., Mol Cell Endocrinol 2003 (Pituitary Neoplasms) : Accordingly, PACAP stimulated AP-1 and CREB transcriptional activity and E ( 2 ) inhibited TRE-LUC but not CRE-LUC activation
McIlvain et al., Brain Res 2006 (Second Messenger Systems) : PACAP38 induced a 4-fold increase in the level of phosphorylation of cAMP-responsive element binding protein ( CREB ) in F11 cells with an EC50 of 130 pM
Shi et al., Mol Cell Biol 2006 : Together, these studies identify an unsuspected connection between cAMP and Rit signaling pathways and imply that Rit can function downstream of G ( s ) alpha/cAMP/Epac in a novel signal transduction pathway necessary for PACAP38 mediated neuronal differentiation and CREB signaling
von Gall et al., Neurobiol Aging 2008 : One of the most robust assays for SCN melatonin receptor activation in mice is the inhibition of PACAP induced phosphorylation of the transcription factor Ca ( 2+ ) /cAMP responsive element binding protein ( CREB ) ... In SCN slices from aged mice ( 19-22 months of age ), PACAP alone induced comparable levels of phospho-CREB , but melatonin treatment failed to inhibit the PACAP induced CREB phosphorylation
Sumner et al., J Mol Neurosci 2008 : PACAP/PAC1 signaling rapidly induced prolonged CREB activation in CG neurons by a phospholipase C -independent mechanism supported by Ca2+-influx, adenylate cyclase, and effectors, including protein kinase C ( PKC ) and possibly PKA
Zhang et al., Cell Signal 2009 (MAP Kinase Signaling System) : Here, we show that PACAP recruits Rap1 into caveolin enriched membrane subdomains in PC12 cells and activates Rap1, nuclear ERK1/2, Elk-1 and CREB in a caveolae dependent manner
Emery et al., FASEB J 2012 : CREB phosphorylation induced by PACAP was blocked by H-89
Schomerus et al., Cell Tissue Res 1996 : Immunocytochemical and immunochemical investigations with an antibody against total CREB showed that stimulation with VIP, PACAP and NE did not affect the level of CREB