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ADCYAP1 — AKT1
Text-mined interactions from Literome
Lee et al., J Biol Chem 2002
:
Moreover,
PACAP induced an increase in activated
Akt through a Trk dependent mechanism that resulted in increased cell survival after trophic factor withdrawal
El Zein et al., Cell Signal 2007
:
K252a, an inhibitor of TrkA decreases
PACAP induced
Akt and ERK phosphorylation and calcium mobilisation resulting in decreases in intracellular H2O2 production and membrane upregulation of CD11b expression, both functions being inhibited after anti-NGF or anti-TrkA antibody treatment
Rácz et al., Regul Pept 2008
(Myocardial Reperfusion Injury) :
PACAP induced the phosphorylation of
Akt and protein kinase A
May et al., J Biol Chem 2010
:
In contrast to the potent and rapid effects of PACAP in ERK1/2 phosphorylation,
PACAP stimulated
Akt phosphorylation in a late phase of PAC(1)HOP1 receptor signaling ... Phosphatidylinositol 3-kinase gamma-selective inhibitors blocked PACAP stimulated Akt phosphorylation in primary neuronal cultures and in PAC(1)HOP1 overexpressing cell lines ; RNA interference mediated knockdown of the receptor effectors attenuated
PACAP mediated
Akt activation ... Between ERK and Akt pathways,
PACAP stimulated
Akt signaling was the primary cascade that attenuated cultured neuron apoptosis after growth factor withdrawal ... The partitioning of
PACAP mediated
Akt signaling in endosomes may be a key mechanism contributing to the high spatial and temporal specificity in signal transduction necessary for survival pathways
Szabo et al., Neurosci Lett 2012
(Carotid Stenosis...) :
Effect of
PACAP on MAP kinases,
Akt and cytokine expressions in rat retinal hypoperfusion