Gene interactions and pathways from curated databases and text-mining

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ADCY6 — IGF1

Text-mined interactions from Literome

Sadler et al., J Biol Chem 1987 : In contrast, insulin-like growth factor 1 stimulated in vivo phosphodiesterase, inhibited in vitro adenylate cyclase , and induced oocyte maturation at concentrations of 0.3-1.0 nM ... These results demonstrate a dual regulation of oocyte phosphodiesterase and adenylate cyclase by insulin and insulin-like growth factor 1
Hakeda et al., J Cell Physiol 1994 : These results indicate that the production of IGF-I and the expression of IGF-I receptors and IGFBP-2 are up-regulated by the activation of adenylate cyclase and protein kinase C, respectively, in osteoblastic MC3T3-E1 cells
Goad et al., Endocrinology 1993 : Taken together, these findings indicated that IGF-I did not affect Gs alpha, coupling of Gs alpha to adenylate cyclase, or adenylate cyclase itself
Fournier et al., J Endocrinol 1993 (Osteosarcoma) : Neither IGF-I nor IGF-II had an effect on either the basal or the parathyroid hormone stimulated level of adenylate cyclase activity, and likewise they had no effect on phosphodiesterase activity
Li et al., Exp Eye Res 1999 (Second Messenger Systems) : SQ22536 ( 100 microM ), an adenylate cyclase inhibitor, and H-89, a PKA inhibitor, had no inhibitory effect on bFGF induced down-regulation of IGF-I expression