Gene interactions and pathways from curated databases and text-mining

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ABL1 — MAPK6

Text-mined interactions from Literome

Klinger et al., Cancer Res 2004 (Breast Neoplasms...) : ABL364 and IGN311 blocked EGF- and heregulin stimulated phosphorylation of mitogen activated protein kinase [ MAPK = extracellular signal regulated kinase 1/2 ] in SKBR-3 and A431 cells
Chu et al., Cancer Res 2007 (Cell Transformation, Neoplastic...) : BCR/ABL expression results in enhanced Ras and Akt activity but reduced mitogen activated protein kinase activity in human hematopoietic cells, which is reversed by BCR/ABL-Y177 mutation
Galan-Moya et al., Int J Cancer 2008 (MAP Kinase Signaling System) : c-Abl activates p38 MAPK independently of its tyrosine kinase activity : Implications in cisplatin based therapy ... Here, we demonstrate that p38 MAPK activation in response to cisplatin does not require the tyrosine kinase activity of c-Abl ... Similar results were obtained in chronic myeloid leukemia derived cell lines, in which a chimeric Bcr/Abl protein mimics the effects of c-Abl overexpression on p38 MAPK activation
Bae et al., Mol Cell Biol 2009 : Cdo is important for full Abl kinase activity, and Abl is necessary for full activation of p38 MAPK , during myogenic differentiation
Modi et al., Leukemia 2011 (Cell Transformation, Neoplastic...) : Inhibition of Grb2 expression demonstrates an important role in BCR-ABL mediated MAPK activation and transformation of primary human hematopoietic cells ... We conclude that inhibition of Grb2 expression demonstrates an important role in BCR-ABL mediated MAPK activation and transformation of primary human hematopoietic cells.These results support further investigation of downstream effectors of Grb2 mediated signals and targeting of Grb2 interactions in the treatment of CML
Redig et al., Leukemia & lymphoma 2011 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : A large body of evidence has established that BCR-ABL regulates engagement and activation of mammalian target of rapamycin (mTOR) and mitogen activated protein kinase ( MAPK ) signaling cascades
Raitano et al., Proc Natl Acad Sci U S A 1995 (Cell Transformation, Neoplastic...) : To examine subsequent signal transduction events we measured the effect of Bcr-Abl on two mitogen activated protein kinase ( MAPK ) cascades -- the extracellular signal regulated kinase ( ERK ) pathway and the Jun N-terminal kinase (JNK) pathway