Bleau et al., Cell stem cell 2009
(Glioma) :
This Akt induced ABCG2 activation results from its transport to the plasma membrane
An et al., PloS one 2012
:
In summary, CSC promotes chemoresistance via Akt mediated regulation of ABCG2 activity, and may also increase the proportion of cancer stem-like cells, contributing to tumor resilience