Gene interactions and pathways from curated databases and text-mining

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ABCC6 — NOS1

Text-mined interactions from Literome

Palomba et al., J Neurochem 2007 (Encephalitis) : Upstream inhibition of the ARA dependent nNOS inhibitory signaling, however, caused the parallel release of superoxide and constitutive NO, thereby leading to formation of ONOO- levels triggering loss of ATP and mitochondrial membrane potential followed by the mitochondrial release of cytochrome c, activation of caspase 3 and morphological evidence of apoptosis ... Thus, the ARA dependent nNOS inhibition observed in astrocytes exposed to pro-inflammatory stimuli, as LPS/IFN-gamma, is critical for both the expression of nuclear factor kappa B-dependent genes and for survival
Cantoni et al., Methods Enzymol 2008 : Proinflammatory factors, as bacterial lipopolysaccharide/interferon-gamma, cause rapid ARA dependent nNOS inhibition, critical for the delayed expression of nuclear factor-kappaB (NF-kappaB) dependent genes as inducible NOS
Palomba et al., J Neurosci Res 2010 (Inflammation) : Early nNOS inhibition mediated by very low levels of ARA is indeed critical for nuclear factor-kappaB activation, which is otherwise effectively inhibited by constitutive nitric oxide, and for preventing early formation of ONOO ( - )