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Text-mined interactions from Literome
Sowa et al., Bioorg Med Chem 2005
:
One of the drugs, 4-fluoro-beta-phenylethylidenehydrazine, was investigated further ex vivo, where it was shown to
inhibit GABA-T , elevate brain levels of GABA, and decrease levels of
glutamine , similar to the profile observed previously for PEH
Paulsen et al., J Neurochem 1988
(Hypoglycemia...) :
Irreversible inhibition of
GABA transaminase by microinjection of gamma-vinyl GABA ( GVG )
led to a decrease in aspartate, glutamate, and
glutamine levels and an increase in the GABA level, such that the nitrogen pool remained constant