Gene interactions and pathways from curated databases and text-mining

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A2M — MAPK6

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Misra et al., J Biol Chem 2002 : Binding of alpha(2)M* to macrophages, moreover, increased phosphorylation of MEK 1/2, ERK 1/2, p38 MAPK , and JNK
Bonacci et al., Arch Biochem Biophys 2007 : Activated alpha(2)-macroglobulin induces cell proliferation and mitogen activated protein kinase activation by LRP-1 in the J774 macrophage derived cell line ... In this work, we demonstrate that alpha(2)M* binding to LRP-1 induces cell proliferation and MAPK activation in the J774 macrophage derived cell line, which were blocked by RAP, an antagonist of LRP-1 binding ligands, and by PD980059, a specific inhibitor for the Mek1-ERK1/2 pathway