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p70S6K1 ⊣ 4E-BP2: " These findings were extended to a cell culture system wherein loss of 4E-BP1 and 4E-BP2 resulted in elevated interaction of p70S6K1 with IGF1 induced activation of mTORC1 in conjunction with an enhanced rate of p70S6K1 phosphorylation at Thr-389 "
p70S6K1 ⊣ 4E-BP1: " These findings were extended to a cell culture system wherein loss of 4E-BP1 and 4E-BP2 resulted in elevated interaction of p70S6K1 with IGF1 induced activation of mTORC1 in conjunction with an enhanced rate of p70S6K1 phosphorylation at Thr-389 "
p70S6K1 ⊣ 4E-BP2: " These findings were extended to a cell culture system wherein loss of 4E-BP1 and 4E-BP2 resulted in elevated interaction of p70S6K1 with IGF1 induced activation of mTORC1 in conjunction with an enhanced rate of p70S6K1 phosphorylation at Thr-389 "
mTORC1 → IGF1: " These findings were extended to a cell culture system wherein loss of 4E-BP1 and 4E-BP2 resulted in elevated interaction of p70S6K1 with IGF1 induced activation of mTORC1 in conjunction with an enhanced rate of p70S6K1 phosphorylation at Thr-389 "
p70S6K1 → mTORC1: " Together, these findings support the conclusion that, in the absence of 4E-BP proteins, mTORC1 mediated phosphorylation of p70S6K1 is elevated by a reduction in competition between the two substrates for interaction with raptor "
p70S6K1 → mTORC1: " Together, these findings support the conclusion that, in the absence of 4E-BP proteins, mTORC1 mediated phosphorylation of p70S6K1 is elevated by a reduction in competition between the two substrates for interaction with raptor "