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insulin ⊣ S6K1: " IL-6 activates S6K1 in these cells, but unexpectedly, S6K1 is not involved in IL-6 inhibition of insulin signaling, since the effect of IL-6 persists in cells with drastically reduced S6K1 levels induced by RNA interference, suggesting that the function of mTOR signaling is through a mechanism different from the prevailing model of S6K1 phosphorylation of insulin receptor substrate-1 "
insulin ⊣ IL-6: " IL-6 activates S6K1 in these cells, but unexpectedly, S6K1 is not involved in IL-6 inhibition of insulin signaling, since the effect of IL-6 persists in cells with drastically reduced S6K1 levels induced by RNA interference, suggesting that the function of mTOR signaling is through a mechanism different from the prevailing model of S6K1 phosphorylation of insulin receptor substrate-1 "
IL-6 ⊣ STAT3: " Interestingly, we find that the phosphorylation of STAT3 on Ser ( 727 ) and STAT3 transcriptional activity are regulated by mTOR upon IL-6 stimulation and that STAT3 is required for IL-6 inhibition of insulin signaling "
IL-6 ⊣ mTOR: " Interestingly, we find that the phosphorylation of STAT3 on Ser ( 727 ) and STAT3 transcriptional activity are regulated by mTOR upon IL-6 stimulation and that STAT3 is required for IL-6 inhibition of insulin signaling "
insulin ⊣ STAT3: " Interestingly, we find that the phosphorylation of STAT3 on Ser ( 727 ) and STAT3 transcriptional activity are regulated by mTOR upon IL-6 stimulation and that STAT3 is required for IL-6 inhibition of insulin signaling "
insulin ⊣ mTOR: " Interestingly, we find that the phosphorylation of STAT3 on Ser ( 727 ) and STAT3 transcriptional activity are regulated by mTOR upon IL-6 stimulation and that STAT3 is required for IL-6 inhibition of insulin signaling "
insulin ⊣ IL-6: " Interestingly, we find that the phosphorylation of STAT3 on Ser ( 727 ) and STAT3 transcriptional activity are regulated by mTOR upon IL-6 stimulation and that STAT3 is required for IL-6 inhibition of insulin signaling "
STAT3 → STAT3: " Interestingly, we find that the phosphorylation of STAT3 on Ser ( 727 ) and STAT3 transcriptional activity are regulated by mTOR upon IL-6 stimulation and that STAT3 is required for IL-6 inhibition of insulin signaling "
STAT3 → mTOR: " Interestingly, we find that the phosphorylation of STAT3 on Ser ( 727 ) and STAT3 transcriptional activity are regulated by mTOR upon IL-6 stimulation and that STAT3 is required for IL-6 inhibition of insulin signaling "
IL-6 ⊣ SOCS3: " Furthermore, IL-6 induced SOCS3 expression is inhibited by rapamycin, and ectopic expression of SOCS3 blocks the ability of rapamycin to enhance insulin sensitivity in the presence of IL-6 "