Gene interactions and pathways from curated databases and text-mining
Cancer Cell 2004, PMID: 14749128

Regulation of tumor angiogenesis by integrin-linked kinase (ILK).

Tan, Clara; Cruet-Hennequart, Severine; Troussard, Armelle; Fazli, Ladan; Costello, Penny; Sutton, Kym; Wheeler, Jeff; Gleave, Martin; Sanghera, Jasbinder; Dedhar, Shoukat

We show that integrin-linked kinase (ILK) stimulates the expression of VEGF by stimulating HIF-1alpha protein expression in a PKB/Akt- and mTOR/FRAP-dependent manner. In human prostate cancer cells, knockdown of ILK expression with siRNA, or inhibition of ILK activity, results in significant inhibition of HIF-1alpha and VEGF expression. In endothelial cells, VEGF stimulates ILK activity, and inhibition of ILK expression or activity results in the inhibition of VEGF-mediated endothelial cell migration, capillary formation in vitro, and angiogenesis in vivo. Inhibition of ILK activity also inhibits prostate tumor angiogenesis and suppresses tumor growth. These data demonstrate an important and essential role of ILK in two key aspects of tumor angiogenesis: VEGF expression by tumor cells and VEGF-stimulated blood vessel formation.

Diseases/Pathways annotated by Medline MESH: Neovascularization, Pathologic
Document information provided by NCBI PubMed

Text Mining Data

HIF-1alpha — mTOR/FRAP: " We show that integrin linked kinase (ILK) stimulates the expression of VEGF by stimulating HIF-1alpha protein expression in a PKB/Akt- and mTOR/FRAP dependent manner "

ILK ⊣ VEGF: " In endothelial cells, VEGF stimulates ILK activity, and inhibition of ILK expression or activity results in the inhibition of VEGF mediated endothelial cell migration, capillary formation in vitro, and angiogenesis in vivo "

VEGF → ILK: " These data demonstrate an important and essential role of ILK in two key aspects of tumor angiogenesis : VEGF expression by tumor cells and VEGF stimulated blood vessel formation "

Manually curated Databases

No curated data.