Description: Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide (YWHAG), mRNA. RefSeq Summary (NM_012479): This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr7:75,956,108-75,988,342 Size: 32,235 Total Exon Count: 2 Strand: - Coding Region Position: hg19 chr7:75,958,894-75,988,125 Size: 29,232 Coding Exon Count: 2
ID:1433G_HUMAN DESCRIPTION: RecName: Full=14-3-3 protein gamma; AltName: Full=Protein kinase C inhibitor protein 1; Short=KCIP-1; Contains: RecName: Full=14-3-3 protein gamma, N-terminally processed; FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. SUBUNIT: Homodimer. Interacts with SAMSN1 (By similarity). Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT. INTERACTION: Q14678-2:KANK1; NbExp=3; IntAct=EBI-359832, EBI-6173812; Q7KZI7:MARK2; NbExp=2; IntAct=EBI-359832, EBI-516560; P27448:MARK3; NbExp=2; IntAct=EBI-359832, EBI-707595; P62258:YWHAE; NbExp=4; IntAct=EBI-359832, EBI-356498; SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Highly expressed in brain, skeletal muscle, and heart. PTM: Phosphorylated by various PKC isozymes. SIMILARITY: Belongs to the 14-3-3 family.
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): YWHAG CDC HuGE Published Literature: YWHAG Positive Disease Associations: Multiple Sclerosis Related Studies:
Multiple Sclerosis Farren B S Briggs et al. Genes and immunity 2011, Genome-wide association study of severity in multiple sclerosis., Genes and immunity.
[PubMed 21654844]
the genetic architecture of disease severity is likely polygenic and comprised of modest effects, similar to what has been described for MS susceptibility, to date.
Multiple Sclerosis Farren B S Briggs et al. Genes and immunity 2011, Genome-wide association study of severity in multiple sclerosis., Genes and immunity.
[PubMed 21654844]
the genetic architecture of disease severity is likely polygenic and comprised of modest effects, similar to what has been described for MS susceptibility, to date.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P61981
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003723 RNA binding GO:0005080 protein kinase C binding GO:0005159 insulin-like growth factor receptor binding GO:0005515 protein binding GO:0008426 protein kinase C inhibitor activity GO:0019904 protein domain specific binding GO:0030971 receptor tyrosine kinase binding GO:0042802 identical protein binding
Biological Process: GO:0000086 G2/M transition of mitotic cell cycle GO:0006469 negative regulation of protein kinase activity GO:0006605 protein targeting GO:0009966 regulation of signal transduction GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0032869 cellular response to insulin stimulus GO:0045664 regulation of neuron differentiation GO:0048167 regulation of synaptic plasticity GO:0061024 membrane organization GO:0071901 negative regulation of protein serine/threonine kinase activity GO:0097711 ciliary basal body docking GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Protein P61981 (Reactome details) participates in the following event(s):
R-HSA-380272 Plk1-mediated phosphorylation of Nlp R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-HSA-380294 Loss of C-Nap-1 from centrosomes R-HSA-380311 Recruitment of Plk1 to centrosomes R-HSA-380455 Recruitment of CDK11p58 to the centrosomes R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome R-HSA-5626220 C2CD3 binds the mother centriole R-HSA-380508 Translocation of NuMA to the centrosomes R-HSA-2574845 AJUBA binds centrosome-associated AURKA R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-3000319 BORA binds PLK1 and AURKA R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation R-HSA-3000310 AURKA phosphorylates PLK1 R-HSA-75016 Association of p-S216-CDC25C with 14-3-3 proteins R-HSA-139899 Sequestration of BAD protein by 14-3-3 R-HSA-1445149 14-3-3 binds p-5S,T642-AS160 (TBC1D4) R-HSA-1454689 14-3-3 Binds p-S237-TBC1D1 R-HSA-5632732 p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 R-HSA-5632738 DDIT4 binds 14-3-3 dimer R-HSA-139906 Activation of BAD by calcineurin R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-HSA-5626681 Recruitment of transition zone proteins R-HSA-5626227 CP110 and CEP97 dissociate from the centriole R-HSA-380316 Association of NuMA with microtubules R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-5626228 The distal appendage proteins recruit TTBK2 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-5626699 MARK4 binds ODF2 in the centriole R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-8854518 AURKA Activation by TPX2 R-HSA-380287 Centrosome maturation R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-5625740 RHO GTPases activate PKNs R-HSA-111447 Activation of BAD and translocation to mitochondria R-HSA-1445148 Translocation of GLUT4 to the plasma membrane R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-5617833 Cilium Assembly R-HSA-68877 Mitotic Prometaphase R-HSA-69275 G2/M Transition R-HSA-69473 G2/M DNA damage checkpoint R-HSA-195258 RHO GTPase Effectors R-HSA-114452 Activation of BH3-only proteins R-HSA-199991 Membrane Trafficking R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-68886 M Phase R-HSA-453274 Mitotic G2-G2/M phases R-HSA-69481 G2/M Checkpoints R-HSA-194315 Signaling by Rho GTPases R-HSA-109606 Intrinsic Pathway for Apoptosis R-HSA-5653656 Vesicle-mediated transport R-HSA-212436 Generic Transcription Pathway R-HSA-69278 Cell Cycle (Mitotic) R-HSA-69620 Cell Cycle Checkpoints R-HSA-162582 Signal Transduction R-HSA-109581 Apoptosis R-HSA-73857 RNA Polymerase II Transcription R-HSA-1640170 Cell Cycle R-HSA-5357801 Programmed Cell Death R-HSA-74160 Gene expression (Transcription)
US Server
