Human Gene WIZ (uc002nbb.4)
  Description: Homo sapiens widely interspaced zinc finger motifs (WIZ), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:15,532,318-15,560,762 Size: 28,445 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr19:15,533,887-15,559,118 Size: 25,232 Coding Exon Count: 7 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:15,532,318-15,560,762)mRNA (may differ from genome)Protein (794 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMalacardsMGI
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: WIZ
Diseases sorted by gene-association score: bladder exstrophy-epispadias-cloacal exstrophy complex (17), asphyxia neonatorum (16), exstrophy of bladder (10), kleefstra syndrome (8)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.41 RPKM in Testis
Total median expression: 529.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -111.30214-0.520 Picture PostScript Text
3' UTR -644.091569-0.411 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on O95785-2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC014220 - Homo sapiens widely-interspaced zinc finger motifs, mRNA (cDNA clone IMAGE:3942047), partial cds.
AL390184 - Homo sapiens mRNA; cDNA DKFZp547M136 (from clone DKFZp547M136).
JD299322 - Sequence 280346 from Patent EP1572962.
JD498867 - Sequence 479891 from Patent EP1572962.
JD234686 - Sequence 215710 from Patent EP1572962.
JD072805 - Sequence 53829 from Patent EP1572962.
JD425524 - Sequence 406548 from Patent EP1572962.
JD319010 - Sequence 300034 from Patent EP1572962.
JD104914 - Sequence 85938 from Patent EP1572962.
BC062360 - Homo sapiens widely interspaced zinc finger motifs, mRNA (cDNA clone IMAGE:4891006), partial cds.
BC002329 - Homo sapiens widely interspaced zinc finger motifs, mRNA (cDNA clone IMAGE:3532992), partial cds.
BC098445 - Homo sapiens widely interspaced zinc finger motifs, mRNA (cDNA clone IMAGE:4565475), partial cds.
AK027615 - Homo sapiens cDNA FLJ14709 fis, clone NT2RP3000605, moderately similar to Mus musculus mRNA for wizL.
AK122890 - Homo sapiens cDNA FLJ16541 fis, clone OCBBF2034823, highly similar to Mus musculus widely-interspaced zinc finger motifs (Wiz), transcript variant 1, mRNA.
AK131404 - Homo sapiens cDNA FLJ16504 fis, clone FEBRA2014122, highly similar to WizL.
JD255699 - Sequence 236723 from Patent EP1572962.
JD448915 - Sequence 429939 from Patent EP1572962.
BC048293 - Homo sapiens widely interspaced zinc finger motifs, mRNA (cDNA clone IMAGE:5246236), with apparent retained intron.
BC007551 - Homo sapiens widely interspaced zinc finger motifs, mRNA (cDNA clone IMAGE:2967126), partial cds.
AK091183 - Homo sapiens cDNA FLJ33864 fis, clone CTONG2006412, highly similar to Mus musculus widely-interspaced zinc finger motifs (Wiz), transcript variant 1, mRNA.
JD381435 - Sequence 362459 from Patent EP1572962.
JD418542 - Sequence 399566 from Patent EP1572962.
JD360803 - Sequence 341827 from Patent EP1572962.
JD402255 - Sequence 383279 from Patent EP1572962.
JD527978 - Sequence 509002 from Patent EP1572962.
JD464479 - Sequence 445503 from Patent EP1572962.
JD191279 - Sequence 172303 from Patent EP1572962.
JD122675 - Sequence 103699 from Patent EP1572962.
BC136641 - Homo sapiens widely interspaced zinc finger motifs, mRNA (cDNA clone MGC:168254 IMAGE:9020631), complete cds.
BC144332 - Homo sapiens widely interspaced zinc finger motifs, mRNA (cDNA clone MGC:177869 IMAGE:9052852), complete cds.
JD334790 - Sequence 315814 from Patent EP1572962.
JD383177 - Sequence 364201 from Patent EP1572962.
JD223619 - Sequence 204643 from Patent EP1572962.
JD373811 - Sequence 354835 from Patent EP1572962.
JD204019 - Sequence 185043 from Patent EP1572962.
JD301796 - Sequence 282820 from Patent EP1572962.
JD555677 - Sequence 536701 from Patent EP1572962.
JD392337 - Sequence 373361 from Patent EP1572962.
JD403513 - Sequence 384537 from Patent EP1572962.
JD228512 - Sequence 209536 from Patent EP1572962.
JD527771 - Sequence 508795 from Patent EP1572962.
JD462642 - Sequence 443666 from Patent EP1572962.
JD395568 - Sequence 376592 from Patent EP1572962.
JD104580 - Sequence 85604 from Patent EP1572962.
JD418646 - Sequence 399670 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_021241, NP_067064, O95785-2, ZNF803
UCSC ID: uc002nbb.4
RefSeq Accession: NM_021241
Protein: O95785-2, splice isoform of O95785 CCDS: CCDS42516.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_021241.2
exon count: 8CDS single in 3' UTR: no RNA size: 4185
ORF size: 2385CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4250.00frame shift in genome: no % Coverage: 99.59
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.