Description: Homo sapiens ribosomal protein L13 (RPL13), transcript variant 1, mRNA. RefSeq Summary (NM_000977): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2011]. Transcript (Including UTRs) Position: hg19 chr16:89,627,065-89,633,237 Size: 6,173 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr16:89,627,368-89,629,450 Size: 2,083 Coding Exon Count: 5
ID:RL13_HUMAN DESCRIPTION: RecName: Full=60S ribosomal protein L13; AltName: Full=Breast basic conserved protein 1; INTERACTION: P16333:NCK1; NbExp=2; IntAct=EBI-356849, EBI-389883; P27986:PIK3R1; NbExp=2; IntAct=EBI-356849, EBI-79464; TISSUE SPECIFICITY: Higher levels of expression in benign breast lesions than in carcinomas. SIMILARITY: Belongs to the ribosomal protein L13e family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P26373
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC106058 - Homo sapiens ribosomal protein L13, mRNA (cDNA clone MGC:117342 IMAGE:4992467), complete cds. BC093063 - Homo sapiens ribosomal protein L13, mRNA (cDNA clone MGC:111169 IMAGE:30401947), complete cds. D28432 - Homo sapiens mRNA for breast basic conserved protein 1, 5'UTR region. AK026501 - Homo sapiens cDNA: FLJ22848 fis, clone KAIA897. AK130964 - Homo sapiens cDNA FLJ27454 fis, clone TST08579, highly similar to 60S ribosomal protein L13. X64707 - H.sapiens BBC1 mRNA. AK294655 - Homo sapiens cDNA FLJ52458 complete cds, weakly similar to 60S ribosomal protein L13. BC066320 - Homo sapiens ribosomal protein L13, mRNA (cDNA clone MGC:87209 IMAGE:5300601), complete cds. AK308545 - Homo sapiens cDNA, FLJ98586. AK290893 - Homo sapiens cDNA FLJ78590 complete cds. AK093246 - Homo sapiens cDNA FLJ35927 fis, clone TESTI2010793. AK130963 - Homo sapiens cDNA FLJ27453 fis, clone TMS02992. AK025405 - Homo sapiens cDNA: FLJ21752 fis, clone COLF6324, highly similar to HSBBC1 Homo sapiens BBC1 mRNA. AK297198 - Homo sapiens cDNA FLJ53059 complete cds, moderately similar to 60S ribosomal protein L13. AK127579 - Homo sapiens cDNA FLJ45674 fis, clone D9OST2004417, highly similar to 60S ribosomal protein L13. BC007345 - Homo sapiens ribosomal protein L13, mRNA (cDNA clone MGC:15415 IMAGE:3688320), complete cds. BC004954 - Homo sapiens ribosomal protein L13, mRNA (cDNA clone MGC:10897 IMAGE:3623320), complete cds. BC006179 - Homo sapiens ribosomal protein L13, mRNA (cDNA clone IMAGE:4054812). BC063378 - Homo sapiens ribosomal protein L13, mRNA (cDNA clone MGC:71373 IMAGE:3542514), complete cds. BC014167 - Homo sapiens ribosomal protein L13, mRNA (cDNA clone MGC:20892 IMAGE:4550361), complete cds. BC007805 - Homo sapiens ribosomal protein L13, mRNA (cDNA clone MGC:14332 IMAGE:4298327), complete cds. BC013078 - Homo sapiens ribosomal protein L13, mRNA (cDNA clone MGC:17534 IMAGE:3459415), complete cds. BC027463 - Homo sapiens ribosomal protein L13, mRNA (cDNA clone MGC:34920 IMAGE:5111302), complete cds. BC010994 - Homo sapiens ribosomal protein L13, mRNA (cDNA clone MGC:15073 IMAGE:3842093), complete cds. BC000851 - Homo sapiens ribosomal protein L13, mRNA (cDNA clone IMAGE:3458439). BC020804 - Homo sapiens ribosomal protein L13, mRNA (cDNA clone MGC:23822 IMAGE:4276103), complete cds. BC007563 - Homo sapiens ribosomal protein L13, mRNA (cDNA clone MGC:15490 IMAGE:2989021), complete cds. BC080536 - Homo sapiens cDNA clone IMAGE:4903971, **** WARNING: chimeric clone ****. AB062392 - Homo sapiens OK/SW-cl.46 mRNA for ribosomal protein L13, complete cds. JD476375 - Sequence 457399 from Patent EP1572962. JD024270 - Sequence 5294 from Patent EP1572962. AB527633 - Synthetic construct DNA, clone: pF1KB5366, Homo sapiens RPL13 gene for ribosomal protein L13, without stop codon, in Flexi system. DQ894636 - Synthetic construct Homo sapiens clone IMAGE:100009096; FLH177119.01L; RZPDo839D04123D ribosomal protein L13 (RPL13) gene, encodes complete protein. DQ891459 - Synthetic construct clone IMAGE:100004089; FLH177122.01X; RZPDo839D04124D ribosomal protein L13 (RPL13) gene, encodes complete protein. KJ905901 - Synthetic construct Homo sapiens clone ccsbBroadEn_15571 RPL13 gene, encodes complete protein. CU678822 - Synthetic construct Homo sapiens gateway clone IMAGE:100018019 5' read RPL13 mRNA. CU680488 - Synthetic construct Homo sapiens gateway clone IMAGE:100023431 5' read RPL13 mRNA. CU688142 - Synthetic construct Homo sapiens gateway clone IMAGE:100021057 5' read RPL13 mRNA. KJ897483 - Synthetic construct Homo sapiens clone ccsbBroadEn_06877 RPL13 gene, encodes complete protein. KJ897484 - Synthetic construct Homo sapiens clone ccsbBroadEn_06878 RPL13 gene, encodes complete protein. KJ897485 - Synthetic construct Homo sapiens clone ccsbBroadEn_06879 RPL13 gene, encodes complete protein. JD035234 - Sequence 16258 from Patent EP1572962. JD192444 - Sequence 173468 from Patent EP1572962. JD424297 - Sequence 405321 from Patent EP1572962. JD163998 - Sequence 145022 from Patent EP1572962. JD233630 - Sequence 214654 from Patent EP1572962. JD490453 - Sequence 471477 from Patent EP1572962. JD046151 - Sequence 27175 from Patent EP1572962. JD480572 - Sequence 461596 from Patent EP1572962. JD222294 - Sequence 203318 from Patent EP1572962. JD222295 - Sequence 203319 from Patent EP1572962. JD231027 - Sequence 212051 from Patent EP1572962. JD271393 - Sequence 252417 from Patent EP1572962. JD197884 - Sequence 178908 from Patent EP1572962. JD412957 - Sequence 393981 from Patent EP1572962. JD412959 - Sequence 393983 from Patent EP1572962. JD513053 - Sequence 494077 from Patent EP1572962. JD286687 - Sequence 267711 from Patent EP1572962. JD105705 - Sequence 86729 from Patent EP1572962. JD071029 - Sequence 52053 from Patent EP1572962. JD102513 - Sequence 83537 from Patent EP1572962. AK095954 - Homo sapiens cDNA FLJ38635 fis, clone HHDPC2001896. HZ461281 - WO 2015190586-A/94: Kit and method for detecting colon cancer. HZ461675 - WO 2015190586-A/488: Kit and method for detecting colon cancer. HZ461927 - WO 2015190591-A/82: Kit and method for detecting breast cancer. HZ462482 - WO 2015190591-A/637: Kit and method for detecting breast cancer. HZ463015 - WO 2015194535-A/109: Kit and method for detecting stomach cancer. HZ463421 - WO 2015194535-A/515: Kit and method for detecting stomach cancer. HZ464326 - WO 2015194615-A/144: Kit or device and method for detecting hepatic cancer. HZ464780 - WO 2015194615-A/598: Kit or device and method for detecting hepatic cancer. HZ465026 - WO 2015194627-A/79: Kit and method for detecting esophageal cancer. HZ465441 - WO 2015194627-A/494: Kit and method for detecting esophageal cancer. HZ480269 - JP 2015535430-A/775: TERMINALLY MODIFIED RNA. HZ790200 - JP 2016504050-A/1945: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. JC512932 - Sequence 3185 from Patent WO2014113089. LF161455 - JP 2016513950-A/1521: Oligomers with improved off-target profile. LF632636 - WO 2016117582-A/65: miRNA biomarkers for mental disorders. LP951765 - Sequence 271 from Patent WO2017157650. LQ070520 - Sequence 844 from Patent EP2964234. LY496209 - KR 1020170018406-A/79: ESOPHAGEAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY496624 - KR 1020170018406-A/494: ESOPHAGEAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY496924 - KR 1020170016485-A/94: COLORECTAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY497318 - KR 1020170016485-A/488: COLORECTAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY498227 - KR 1020170018411-A/144: LIVER CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY498681 - KR 1020170018411-A/598: LIVER CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY498930 - KR 1020170018412-A/82: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER. LY499485 - KR 1020170018412-A/637: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER. LY499828 - KR 1020170019425-A/109: STOMACH CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY500234 - KR 1020170019425-A/515: STOMACH CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LZ238352 - WO 2017171048-A/13: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas. LZ238872 - WO 2017171048-A/533: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas. MS880245 - Sequence 82 from Patent EP3156498. MS880800 - Sequence 637 from Patent EP3156498. MS884111 - Sequence 94 from Patent EP3156499. MS884505 - Sequence 488 from Patent EP3156499. MS884947 - Sequence 109 from Patent EP3156503. MS885353 - Sequence 515 from Patent EP3156503. MS994217 - Sequence 79 from Patent EP3159406. MS994632 - Sequence 494 from Patent EP3159406. DQ575437 - Homo sapiens piRNA piR-43549, complete sequence. JD367442 - Sequence 348466 from Patent EP1572962. JD421101 - Sequence 402125 from Patent EP1572962. JD443020 - Sequence 424044 from Patent EP1572962. JD335422 - Sequence 316446 from Patent EP1572962. JD104356 - Sequence 85380 from Patent EP1572962. JD287804 - Sequence 268828 from Patent EP1572962. JD335423 - Sequence 316447 from Patent EP1572962. JD335424 - Sequence 316448 from Patent EP1572962. JD388487 - Sequence 369511 from Patent EP1572962. JD118532 - Sequence 99556 from Patent EP1572962. MA644021 - JP 2017113010-A/1945: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. MA731905 - JP 2017140048-A/775: TERMINALLY MODIFIED RNA. MA405780 - WO 2018155427-A/554: A probe with reduced false positive binding, a method to desing the probe, and the use thereof. MA801074 - JP 2018183181-A/1945: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. MA822222 - WO 2019004436-A/35: Kit, device, and method for detection of lung cancer. MA822890 - WO 2019004436-A/703: Kit, device, and method for detection of lung cancer. LY616116 - KR 1020180129785-A/13: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR. LY616636 - KR 1020180129785-A/533: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR. MB472652 - WO 2019208671-A/51: Kit or device and method for detecting bladder cancer. MB473145 - WO 2019208671-A/544: Kit or device and method for detecting bladder cancer.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03010 - Ribosome
Reactome (by CSHL, EBI, and GO)
Protein P26373 (Reactome details) participates in the following event(s):
R-HSA-72672 The 60S subunit joins the translation initiation complex R-HSA-156826 Dissociation of L13a from the 60s ribosomal subunit R-HSA-72673 Release of 40S and 60S subunits from the 80S ribosome R-HSA-72671 eIF5B:GTP is hydrolyzed and released R-HSA-156907 Aminoacyl-tRNA binds to the ribosome at the A-site R-HSA-2408529 Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome R-HSA-141691 GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex R-HSA-156915 Translocation of ribosome by 3 bases in the 3' direction R-HSA-141671 Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex R-HSA-156912 Peptide transfer from P-site tRNA to the A-site tRNA R-HSA-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex R-HSA-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) R-HSA-156923 Hydrolysis of eEF1A:GTP R-HSA-5333615 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC R-HSA-141673 GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-156827 L13a-mediated translation R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-72737 Cap-dependent Translation Initiation R-HSA-72613 Eukaryotic Translation Initiation R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-156902 Peptide chain elongation R-HSA-2408557 Selenocysteine synthesis R-HSA-72764 Eukaryotic Translation Termination R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-72766 Translation R-HSA-376176 Signaling by ROBO receptors R-HSA-192823 Viral mRNA Translation R-HSA-72312 rRNA processing R-HSA-156842 Eukaryotic Translation Elongation R-HSA-2408522 Selenoamino acid metabolism R-HSA-927802 Nonsense-Mediated Decay (NMD) R-HSA-392499 Metabolism of proteins R-HSA-422475 Axon guidance R-HSA-168273 Influenza Viral RNA Transcription and Replication R-HSA-8953854 Metabolism of RNA R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-1266738 Developmental Biology R-HSA-168255 Influenza Life Cycle R-HSA-1430728 Metabolism R-HSA-168254 Influenza Infection R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
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