ID:REBL1_HUMAN DESCRIPTION: RecName: Full=GTPase RhebL1; AltName: Full=Ras homolog enriched in brain like-1 c; Short=RhebL1c; AltName: Full=Ras homolog enriched in brain-like protein 1; Short=Rheb-like protein 1; AltName: Full=Rheb2; Flags: Precursor; FUNCTION: Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2. SUBUNIT: Interacts with MTOR. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Cytoplasm. TISSUE SPECIFICITY: Ubiquitously expressed. Expression increased at least 2-fold in several tumor cell lines. SIMILARITY: Belongs to the small GTPase superfamily. Rheb family. SEQUENCE CAUTION: Sequence=AAS80166.1; Type=Erroneous translation; Note=Wrong choice of CDS;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TAI7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
